Evidence that estrogen receptors play a limited role in mediating enhanced recovery of bile flow in female rats in the acute phase of liver ischemia reperfusion injury
Journal Title: Annals of Hepatology - Year 2013, Vol 12, Issue 1
Abstract
[b]Introduction[/b]. Female patients exhibit better survival and less hepatic damage from ischemia reperfusion (IR) injury following surgery. However, the effects of sex and estrogens on liver function in the acute phase of IR are not well understood. [b]Objective[/b]. The aim was to investigate this question. [b]Material and methods. [/b]A rat model of segmental hepatic ischemia was employed. Rats were pre-treated with the estrogen receptor antagonist ICI182,780 and/or the estrogen receptor agonist 17β-estradiol. Bile flow, blood concentrations of bilirubin and liver enzymes were measured, and liver histology was assessed. [b]Results[/b]. Bile flow recovery immediately after the initiation of reperfusion was faster in females than in males. ICI182,780 reduced the rate of bile flow recovery in females but this reduction was not reversed by co-administration of 17 β-estradiol. In males, 17 β-estradiol alone did not enhance bile flow recovery. The changes in bile flow recovery observed under a given condition were correlated with small changes in blood liver enzymes and liver histology. [b]Conclusions[/b]. Sex has a significant influence on the early recovery of liver function in the acute phase of IR injury. However, in female rats estrogen receptors play only a limited role in mediating enhanced recovery of liver function.
Authors and Affiliations
Fraukje Ponds, Heleen de Vries, Vincent Nieuwenhuijs, Arthur Morphett, Robert Padbury, Greg Barritt
Keywords
Related Articles
- EP ID EP78241
- DOI -
- Views 82
- Downloads 0
Impact of the severity of end-stage liver disease in cardiac structure and function
[b]Background[/b]. The impact of end-stage liver disease (ESLD) in cardiac remodeling of patients with cirrhosis is unknown. Our aim was to correlate the severity of ESLD with morphologic and functional heart changes. [b...
Risk factors for and management of ischemic-type biliary lesions following orthotopic liver transplantation: A single center experience
Introduction. Biliary complications can cause morbidity, graft loss, and mortality after liver transplantation. The most troublesome biliary complications are ischemic-type biliary lesions (ITBL), which occur since trans...
Association between serum IgE level and adverse clinical endpoints in primary sclerosing cholangitis
Introduction. Primary sclerosing cholangitis (PSC) is an idiopathic hepatobiliary disorder associated with an increased risk for cholangiocarcinoma (CCA) and a median survival time of 12 years. Reliable predictors of CCA...
Epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD)
[b][/b]The authors summarize and update the most recent knowledge in the field of prevalence, natural history and incidence of Non Alcoholic Fatty Liver Disease (NAFLD) and Non Alcoholic Steatohepatitis (NASH). These nov...
Recurrent pyogenic cholangitis in a case with congenital biliary anomaly
Recurrent pyogenic cholangitis is endemic to South-east Asia but has been very rarely reported from natives of other parts of the world. A 43-years-old woman was presented with sepsis that had a history of recurrent epig...