Evolution of hepatitis B virus during long-term therapy in patients with chronic hepatitis B
Journal Title: Annals of Hepatology - Year 2011, Vol 10, Issue 4
Abstract
Background. Long-term lamivudine (LAM), adefovir (ADV) and entecavir (ETV) treatment induce the emergence of drug-resistant hepatitis B virus (HBV) in patients with chronic hepatitis B infection. Aim. To evaluate the LAM, ADV and ETV resistance mutations detected in our patient group. Materials and methods.Twenty patients who had received at least two years of treatment with nucleoside/tide analogues were enrolled in this study. Patients with detectable HBV DNA were analyzed in order to detect resistance mutations and in this group of patients treatment was change. Results. Three patients developed LAM resistance mutations (2 presented rtM204I and one rtL180M+rtM204V/I) and one patient showed rtN236T ADV resistance mutation. During ADV and LAM treatment, one patient developed ADV plus LAM resistance mutations (rtI163V+rtL180M+rtA181V+rtN236T), in this case, HBV strains harbouring polymerase mutations did not develop LAM associated rtM204V/I primary mutation. In addition, ETV resistance mutations (rtL180M+rtT184A+rtS202G+rtM204V) were detected in one patient. Conclusions. These findings suggest that monotherapy resulted in a limited virological response and combination strategies including potent antiviral agents should be recommended for patients with resistant mutations.
Authors and Affiliations
Elisabete Arrese, Miren Basaras, Sonia Blanco, Pablo Ruiz, Ramón Cisterna
Keywords
Related Articles
- EP ID EP78072
- DOI -
- Views 112
- Downloads 0
No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C
Background. Heme oxygenase-1 (HMOX1) and bilirubin UDP-glucuronosyltransferase (UGT1A1), both enzymes involved in bilirubin homeostasis, play an important role inoxidative stress defense. Objective. To assess the effect...
Inflammation is not the cause of an elevated serum ferritin in non-alcoholic fatty liver disease
Background. In non-alcoholic fatty liver disease (NALFD), it has often been assumed that an elevation in serum ferritin is likely related to inflammation rather than iron overload. Material and methods. Patients referred...
Effect of cholecystectomy on bile acid synthesis and circulating levels of fibroblast growth factor 19
Background and rationale for the study. FGF19/15 is a gut-derived hormone presumably governing bile acid (BA) synthesis and gallbladder (GB) refilling. FGF19 mRNA is present in human GB cholangiocytes (hGBECs); however,...
Profile of idiosyncratic drug induced liver injury in Latin America. An analysis of published reports
Introduction. Drug-induced liver injury (DILI) remains a major problem for drug development and represents a challenging diagnosis for clinicians. The absence of specific biomarkers for diagnosing DILI precludes the avai...
Association between metabolic abnormalities and hepatitis C-related hepatocellular carcinoma
Background and aim. Metabolic syndrome is recognised as a potential risk factor for the development of hepatocellular carcinoma (HCC). The association between metabolic factors and hepatitis C (HCV)-related HCC has not...