EVOLUTION OF THE HAEMATOLOGICAL INDICES AT CD1 MICE WITH INDUCED DIABETES, TREATED WITH VEGETAL EXTRACTS OF ARONIA MELANOCARPA AND SILYBUM MARIANUM
Journal Title: Current Trends in Natural Sciences - Year 2017, Vol 6, Issue 12
Abstract
The aim of this paper is to investigate the effects produced by the vegetal extracts of Aronia melanocarpa and Silybum marianum on the haematological index at CD1 (the rederived mice from a non-consanguineous strain) mice with artificially induced diabetes. We established the number of haematites and leucocytes, as well as their morphological dimension and aspect on the blood smear. The diabetisation of the mice was carried out by administering two doses of 0.2 ml solution of Alloxan (130mg/kg body, dissolved in physiological saline), following which, during two weeks, vegetal extract of aronia and milk thistle was administered (0,2 ml). The results obtained showed that there are no significant changes of the number of haematites and leucocytes in comparison with the witness lot. As for the aspect and the dimensions of the figurate elements on the blood smear, in the case of the lot injected with alloxan monohydrate, it was noticed an increase of the haematites’ volume and the apparition of some atypical cells – megalocytes, as well as the presence of apoptosis nuclei. Following the administration of the vegetal extracts of aronia and milk thistle, we notice a comeback of the haematites’ dimension, as well as the lack of apoptosis micronuclei, which demonstrates the beneficial effect of the two extracts.
Authors and Affiliations
Monica Bucă, Magdalena Cristina Zagardan, Mădălina Elena Scarlat, Claudiu Alexandru Baciu, Monica Popescu, Alina Păunescu, Cristina Maria Ponepal, Alexandru Gabriel Marinescu
Keywords
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