Exercise Training And Molecular Markers: New Perspectives In The Rehabilitation Of COPD
Journal Title: Drug Designing & Intellectual Properties International Journal - Year 2018, Vol 1, Issue 4
Abstract
Chronic Obstructive Pulmonary Disease (COPD), as defined in the recent revision of the Global Strategy for the Diagnosis (GOLD) guidelines, is a common, preventable and treatable disease characterized by persistent respiratory symptoms and airflow limitation, which is due to airway and alveolar abnormalities usually caused by significant exposure to harmful particles or gases. The chronic limitation to airflow characteristic of COPD is caused in part by changes in small airways (obstructive bronchiolitis) and in part by parenchymal destruction (emphysema). In addition to the clinical evaluation of the symptomatic picture and a careful history, for the diagnosis of COPD it is necessary to perform a spirometry. The presence of a post-bronchodilator FEV1/ FVC ratio <0.70 confirms the presence of persistent bronchial obstruction [1]. Dyspnea is certainly an element that we find in all patients with COPD to varying degrees, and this triggers a vicious circle that leads patients to reduce physical activity, causing an even more precocious appearance of dyspnea and muscle fatigue with reduced performance in Activity of Daily Living (ADL). The classic rehabilitation proposal includes an intervention focused on exercise training, although there is still a lot to do to clearly define the right amount of exercise that is safe and effective for each patient [2].
Authors and Affiliations
Garofano M, Ascoli MM, Aliberti M, Calabrese M, M Ciriello
Keywords
Related Articles
- EP ID EP587209
- DOI 10.32474/DDIPIJ.2018.01.000119
- Views 154
- Downloads 0
Preparation of Polyelectrolyte Hydrogels and Study Their Controlled Release of Gabapentin
The semi interpenetrating network hydrogels (Z1-Z15) were prepared from different ratio of sodium alginate and linear poly (acrylamide-co-diallyl dimethyl ammonium chloride) then they mixed with the acrylamide and bisacr...
Development of Some Eco-Efficient and Selective Chemical Processes and Products Using Sustainable and Green Chemistry Approaches
Historical records show that scientific advancements accounted for substantial changes in our life-style and wellbeing. The Industrial Revolution took place in the western countries in the 1700s when people first appreci...
Genotoxic Impurities and Its Risk Assessment in Drug Compounds
The present work is based on a assess analysis of the literature in order to define the genotoxic impurities present in the drug substances and drug products. Starting from the definition of genotoxic impurities, sources...
FTIR Analysis & Dielectric Constant for Some Iron Bismuth Borate Glasses
Borate glasses contain transition metal ions are of high importance in science and technology, as solid electrolytes and electric sensors [1]. Oxide glasses, especially bismuth borate glasses, are considered as stable ac...
From Merck's CCK- Antagonists Via 4-Amino-2(5H)- Furanones towards 5-Hydroxy-Pyrrol-2-Ones: Design, Synthesis and Evaluation of PNB-001 & PNB-081 as Experimental Therapeutic Agents in Pain Management
Arylated 5-hydroxy-pyrrol-2-ones were prepared in 2 synthetic steps from muco-chloric acid and were optimised as CCK / CCK2 selective ligands using radio labelled binding assays. A potent CCK selective ligand was identif...