Experimental asthma in rats.
Journal Title: Pharmacological Reports - Year 2008, Vol 60, Issue 6
Abstract
Animal models of asthma have been used for over 100 years. The accuracy of extrapolations from animal models to human asthmatics is highly dependent on the species of animal selected. The rat, in comparison with other animals, demonstrates many features of airway allergy and allergic asthma that are similar to the human conditions. The following features of human asthma can be effectively investigated in a rat model of the disease: cellular infiltration of the lung, antigen-specific IgE production, and a predominant Th2 response. The majority of available models of asthma are restricted to the acute inflammatory response following a short period of allergen exposure. The frequently used model of ovalbumin (OVA) sensitization and challenge replicates the inflammatory process in the airways.
Authors and Affiliations
Iwona Kucharewicz, Anna Bodzenta-Łukaszyk, Włodzimierz Buczko
Keywords
Related Articles
- EP ID EP154908
- DOI -
- Views 88
- Downloads 0
Anti-inflammatory and antinociceptive effects of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine in mice.
Background: QUAN-0808 (6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine), a new phthalazine tetrazole derivative, was evaluated for the anti-inflammatory and analgesic effects. Methods: Xylene-induced ear edema, carrageen...
Comparative evaluation of the protective effect of selenium and garlic against liver and kidney damage induced by mercury chloride in the rats.
The present study was designed to compare the protective effect of selenium and garlic against liver and kidney damage induced by (ip) injection of 0.5 mg/kg mercury chloride (HgCl(2)) in rats. Thirty-six Sprague-Dawley...
Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys.
Quercetin, a typical bioflavonoid ubiquitously present in fruits and vegetables, is considered to be helpful for human health. Cisplatin (cDDP) is one of the most active cytotoxic agents in the treatment of a wide range...
α1-Adrenergic receptor subtypes in the central nervous system: insights from genetically engineered mouse models.
α1-Adrenergic receptors (α1-ARs) are important players in peripheral and central nervous system (CNS) regulation and function and in mediating various behavioral responses. The α1-AR family consists of three subtypes, α1...
New light on the anti-colitic actions of therapeutic aminosalicylates: the role of heme oxygenase.
Although a variety of pharmaceutical preparations of aminosalicylate are commonly used in the clinic for the control of inflammatory bowel disease, the mechanisms underlying their therapeutic actions remain unclear. Rece...