Experimental Design Techniques Applied to Study of Oxygen Consumption in a Fermenter
Journal Title: Journal of Applied Quantitative Methods - Year 2007, Vol 2, Issue 1
Abstract
The dependence of the volumetric rate of oxygen consumption on the variables agitation and air flow, was studied in a laboratory scale fermenter. A 22 factorial experimental design, with four axial points and four replicates of the central point, was used. The coefficients for the two-variables, quadratic model were calculated. The 'fit' of the model with the empirical data was studied using a lack of fit test. The surface response methodology was used to maximize the dependent variable, volumetric rate of oxygen consumption. The response surface obtained showed an absolute maximum on the domain’s boundary, consistent with theoretical considerations indicating that a relative maximum inside the domain was impossible. This approach allowed us to derive a model to predict volumetric rate of oxygen consumption in a standard laboratory fermenter, as a function of agitation and air flow, i.e., the two variables selected.
Authors and Affiliations
Blanca VELÁZQUEZ, Víctor MARTÍNEZ-LUACES, Adriana VÁZQUEZ, Valerie DEE, Hugo MASSALDI
Keywords
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