Experimental evaluation of the influence of gold nanoparticles and cerium dioxide on normal and malignant cells and tissues
Journal Title: Медичні перспективи - Year 2017, Vol 22, Issue 3
Abstract
The results of experimental studies of the effect of gold nanoparticles (AuNPs) on the organs of the reproductive system of male rats, cells and tissues of androgen-dependent prostate cancer (PCa) are presented, as well as the effect of cerium dioxide nanoparticles (CeO2NPs) on the testes and fertility of aging male rats. Addition of polydisperse colloidal solution of AuNPs (10-50 nm) to the culture medium in a final concentration of 10 μg/ml inhibited the growth of the LNCaP culture, PCa cells, while monodisperse solution of AuNPs (20 nm) caused no effect. The polydisperse colloidal solution of AuNPs arrested the growth of PCa xenografts in mice, when administered parenterally at a dose range of 0.64-6.4 μg/kg body weight. The selectivity of the drug effect on the malignant epithelium is confirmed by signs of its destruction and decrease in the epithelial stromal ratio on histological preparations of xenografts. There was no significant damaging effect of poly- and monodisperse AuNPs solutions on the organs of the reproductive system of male rats when administered for up to two weeks. The stimulating effect of a low dose of CeO2NPs (1 mg/kg b.w.) administered orally on hormonal function of testes and spermatogenesis, proliferative and secretory processes in the prostate of aging male rats was established. However, fertility of animals was reduced in comparison with the control group due to immaturity of the part of spermatozoa. Thus, metal nanoparticles and their salts can have both a stimulating and destructive effect on organs and tissues, which should be taken into consideration when studying their therapeutic potential and in toxicology.
Authors and Affiliations
A. G. Reznikov, O. A. Falyush, N. D. Nosenko, O. V. Sachynska, L. I. Polyakova, A. A. Limareva, I. G. Perchyk
Keywords
Related Articles
- EP ID EP229876
- DOI 10.26641/2307-0404.2017.3.111856
- Views 126
- Downloads 0
Катамнез случая органического галлюциноза при макроаденоме гипофиза
В статье приведено годичное катамнестическое исследование описанного нами в предыдущей статье клинического случая органического галлюциноза у пациента с макроаденомой гипофиза. При первичном поступлении в стационар (год...
Гігієнічні основи професіографічної оцінки стоматологічних спеціальностей та перспективи її використання у практиці сучасної профілактичної медицини
Профессиография трудовой деятельности является важнейшей составляющей современной системы профессиональной ориентации. В ходе исследований, целью которых была разработка гигиенических основ профессиографической оценки ос...
Normative workload on physicians of ophthalmological in-hospital departments of intensive care hospital, depending on the volume of work performed
The research was done with the application of “Methodology of definition of normative workload of physicians of in-hospital departments of intensive care hospitals” approved by the Ministry of health care of Ukraine on t...
Staged isolation of abdominal cavity in generalized on peritonitis
In the work we present comparative results of treatment of patients with generalized secondary and tertiary peritonitis depending on the way of surgery completion. Patients in group I (n=27) underwent only skin suturing...
Optimization of surgical treatment of epidermoid brain tumors
. Despite the relatively rare occurrence of epidermoid brain tumors (EBT), high rates of postoperative mortality and a high incidence of tumor recurrence are marked in the operated patients. The purpose of research is to...