EXPERIMENTAL MODELING OF 1ST AND 2ND DEGREES ALKALI ESOPHAGUS BURN IN IMMATURE RATS
Journal Title: Naukovyi visnyk Chernivetskoho universytetu. Biolohiia (Biolohichni systemy) - Year 2014, Vol 6, Issue 1
Abstract
thologies and complications following an alkali esophageal burns: swelling of the larynx, toxic shock syndrome, necrosis of esophageal and stomach tissue, dysmotility, scar stricture, esophageal deformations, corrosive esophagitis, gastroesophageal reflux, malignization in a remote period and others. Esophageal burns as a result of accidental swallowing of caustic material are seen frequently in children ages 1 to 8 years. Today there are a number of experimental models of an alkali esophagus burns (AEB) which require the use of chemicals for their creation where, in itself, they affect the certain biochemical parameters, which complicates the interpretation and analysis of the experimental results. The comparison of the detected lesions and researches of status of the esophageal mucosa of children with 1st and 2nd degree burns specified the experimental model conformity. Therefore, one of the major diagnostic criteria of the AEB severity is to determine biochemical parameters. We selected the following indicators as the level of total protein, albumin, urea, potassium ions, creatinine, AST, ALT, which are the main biochemical parameters of blood serum. Thus, we have reproduced the model of the 1st and 2nd degree an alkali esophageal burns using 10% and 20% NaOH which was accompanied by corresponding morphological lesions of esophageal mucosa and changes in basic biochemical parameters. This approach may be used in the study of biochemical and immunological mechanisms of pathogenesis of the 1st and 2nd degree an alkali esophageal burns of on animals.
Authors and Affiliations
Я. Раєцька, Т. Іщук, О. І. О. І. ДЖУС, О. Савчук, Л. І. ОСТАПЧЕНКО
Keywords
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