EXPERIMENTAL MODELS FOR HEPATOTOXICITY
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
The liver is among the most complex and important organs in the human body. Hepatotoxicity is a leading cause of morbidity and mortality, and itsprevalence is continuously increasing day by day in the industrialized nations. Hepatotoxicity is characterized by nuclear pyknosis and eosinophiliccytoplasm, followed by large excessive hepatic lesion, fatty changes, lipid peroxidation leads to hepatic centrilobular necrosis. Paracetamol,anti‑tubercular drugs, alcohol, and azathioprine are considered to be the major risk factors implicated in the progression of hepatotoxicity. Varioussignaling mechanisms, such as activation of innate immune system like Kupffer cells, natural killer (NK) cells, and NKT, inflammatory mediators,intracellular Ca2+ concentration and reactive oxygen species are involved in the pathogenesis of hepatotoxicity. At present, there is no promising therapyis available to treat patients with hepatotoxicity due to lack of understanding of signaling culprits involved in the pathogenesis of hepatotoxicity.Animal models are being developed to better understand the disease pathogenesis and develop drugs for hepatotoxicity. In the present review, wehave discussed various experimental models for hepatotoxicity, which may open vistas for developing new drugs to treat hepatotoxicity.Keywords: Hepatotoxicity, Carbon tetrachloride, Serum glutamic oxalacetic transaminase, Natural killer T, etc.Â
Authors and Affiliations
Gurfateh Singh, Nancy Dhadwal, S. l. Harikumar
Keywords
Related Articles
- EP ID EP605624
- DOI -
- Views 104
- Downloads 0
BENEFICIAL OUTCOMES AFTER COMBINED THERAPY WITH AZATHIOPRINE AND PIOGLITAZONE IN PRECLINICAL ARTHRITIC MODELS
Objectives: The present study was designed to investigate the antioxidant and anti-arthritic activities of azathioprine-pioglitazone combination therapy to check whether it has an add on benefit over monotherapy with aza...
LEVONORGESTREL-RELEASING INTRAUTERINE SYSTEM IN ADENOMYOSIS; PREDICTORS FOR RESPONSE AND CLINICAL OUTCOME
Objectives: The aim is to detect clinical and ultrasonographic characters that predict the response of adenomyosis to levonorgestrel-releasing intrauterine system (LNG-IUS) and to evaluate the clinical efficacy and the t...
MICRONUCLEI - AS A BIOMARKER OF GENOTOXICITY IN AUTOMOBILE MECHANICS OF WESTERN MAHARASHTRA
  Objective: The aim of this study was to assess the potential cytogenetic damage associated with occupational exposure to polycyclic aromatic hydrocarbons (PAHs) among automobile mechanics (AMs) using micronuclei (MNs...
SYNTHESIS, SPECTRAL CHARACTERIZATION, AND ANTIPROLIFERATIVE ACTIVITY OF DISPIROPYRROLIDINES CONTAINING 2-THIOXOTHIAZOLIDIN-4-ONE NUCLEUS
Objective: Spiro compounds are present in nature, endowed with deep biological activities. Heterocyclic compounds with a pyrrolidine scaffold are one of the paradigms of organic chemistry that exhibits a wide variety of...
DESIGN AND SYNTHESIS OF NOVEL 4-(4-FLUORO-3-METHYLPHENYL)-6-(SUBSTITUTED ARYL)-1,6-DIHYDROPYRIMIDIN-2-OL DERIVATIVES AS POTENT ANTI-INFLAMMATORY AND ANALGESIC AGENTS
Objective: Pyrimidine heterocycles possessing hydroxy group has a unique place in medicinal chemistry and also plays a key role in biological processes. In the biological functions at cellular level pyrimidine plays impe...