Experimental study of anti-inflammatory activity of the new combined with drug urolytolytic action 

Journal Title: Медичні перспективи - Year 2015, Vol 20, Issue 2

Abstract

Herbal medicines provide their versatile complex influence on the course of the pathological process in the kidneys due to biologically active compounds. Specifically, they cause the direct impact on the concrements formation. The search of drugs which would contain high biological compounds of plant origin is an actual issue of modern pharmacology. The aim of investigation was to study the anti-inflammatory activity of the new combined drug of urolytolytic action, which includes the total plant extract and succinate buffer complex. Materials and methods: aseptic exudative inflammation was caused by subplantar introduction of 0,1 ml of 1% solution of λ-karahenin in the right hind paw of rats, the investigated drug was administered at doses 1, 2 and 4 ml/kg. The influence of the studied drug was evaluated in terms of swelling limbs volume. It is shown that the severity of antiexudative action of flarosukcine had dose-dependent nature, increasing from dose of 1,0 ml/kg to 2,0 ml/kg (by 5,5%). Further dose increase to 4,0 ml/kg, was not defined by significant increase of activity. Anti-inflammatory activity of the drug ranged from 25 to 33%, which can be regarded as quite distinct, since in pharmacological study of anti-inflammatory drugs pharmacological activity level of at least 20% is significant. 

Authors and Affiliations

T. Iermolenko

Keywords

Related Articles

Ефективність рофлуміласту, урсодезоксихолієвої кислоти та нуклеїнату у хворих на хронічне обструктивне захворювання легень із супровідним хронічним некаменевим холециститом

Глобальная инициатива по диагностике, лечению и профилактике ХОБЛ недавно включила рофлумиласт (Р) – ингибитор фосфодиэстеразы-4 (ФДЭ-4) в качестве нового терапевтического средства в рекомендации по ведению пациентов с Х...

Clinical features of development of chronic cerebral ischemia against background of pronounced decrease of cognitive functions

The paper presents the results of analyses of cognitive failure in chronic cerebral ischemia (CCI) with lesion of deep divisions of the brain white matter and basal ganglia, leading to disruption of communication of fron...

Стан катехоламінергічних систем мозку при формуванні сиднокарбового психозу

Нарушения мнестических реакций являются одними из существенных признаков расстройств нервной деятельности. На основании этого, в качестве критерия формирования экспериментального психоза, в наших наблюдениях было изучено...

A case report of cardiogenic syncope in the adolescent

The article presents authors’ observation of a clinical case of the girl aged 15 years old with cardiogenic syncope due to sick sinus syndrome, which progressed from normocardia sinus rhythm to pauses of the cardiac rhyt...

Комплексное лечение генерализованного катарального гингивита с предвестниками раннего формирования деструктивных явлений в костных структурах пародонта

Комплексне лікування генералізованого катарального гінгівіту з передвісниками раннього формування деструктивних явищ у кісткових структурах пародонту. Гудар’ян О.О., Струк В.И., Ватаманюк Н.В. У статті представлені резул...

Download PDF file
  • EP ID EP116870
  • DOI -
  • Views 96
  • Downloads 0

How To Cite

T. Iermolenko (2015). Experimental study of anti-inflammatory activity of the new combined with drug urolytolytic action . Медичні перспективи, 20(2), 25-29. https://europub.co.uk/articles/-A-116870