Exploration of the relationship between the storage time of leukodepleted red blood cell and transfusion adverse reactions
Journal Title: Chinese Journal of Blood Transfusion - Year 2023, Vol 36, Issue 10
Abstract
Objective To explore the relationship between the storage time of leukodepleted red blood cells and transfusion adverse reactions by analyzing the occurrence of transfusion adverse reactions of patients after leukodepleted red blood cells transfusion from four hospitals. Methods By using the electronic medical record management system, the collection and transfusion dates of leukodepleted red blood cells from four hospitals in Enshi Prefecture from 2018 to 2022, as well as the information on transfusion adverse reactions, were retrieved. Results From 2018 to 2022, a total of 697 61 bags of leukodepleted red blood cells were transfused in four hospitals, resulting in 166 cases of transfusion adverse reactions, among which 93 were allergic reactions, 63 were non hemolytic febrile reactions, and 10 were others, with a total incidence rate of transfusion adverse reactions at 0.24%. The average storage time of leukodepleted red blood cells with and without transfusion adverse reactions was (20.25±6.31) and (19.88±5.50) days, respectively. With a storage time of 7 days as the threshold, the incidence of transfusion adverse reactions was the lowest for a storage time of 15~21 days. The incidence of transfusion adverse reactions of leukodepleted red blood cells in two groups (with storage days ≤21 days and >21 days) was not statistically significant(P>0.05). Conclusion Allergic reactions were the main type of transfusion adverse reaction caused by leukodepleted red blood cells, and the incidence of transfusion adverse reactions decreased and then increased with the prolongation of the storage time of leukodepleted red blood cells. There was no significant difference in the incidence of transfusion adverse reactions with leukodepleted red blood cells stored for ≤ 21 days and >21 days.
Authors and Affiliations
Liu HE, Jian LIU, Gang WU, En WANG, Fayan YI, Xingshun TAN, Shiyu ZHU, Rui YU, Guanghui LU, Yan LIU, Mei ZHAI, Qing XIANG, Ping LIU, Yanhua LIAO, Zhizhen FU, Maolin LI, Rong HUANG
Keywords
Related Articles
- EP ID EP738659
- DOI 10.13303/j.cjbt.issn.1004-549x.2023.10.008
- Views 36
- Downloads 0
Adverse reactions to blood transfusion: A retrospective analysis of 814 cases in Qingdao area from 2020 to 2021
Objective To investigate the incidence and composition of adverse reactions to blood transfusion(ARBT) in Qingdao hospitals in recent years. Methods The "Statistical Table of Adverse Reactions to Blood Transfusion in Med...
Addressing blood safety implications of donors using HIV antiretroviral therapy
HIV infection and transmission is a serious threat to people's health and public health security. Antiretroviral therapy (ART), including pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP), has played a...
The influence of sporadic cases of COVID-19 on the work of Transfusion Department and its countermeasures
Objective To analyze the impact of sporadic cases of COVID-19 on the work of Transfusion Department, so as to explore the countermeasures. Methods The admission of inpatient departments, the reception of outpatient(inclu...
Clinical application of thromboelastography in the prevention of lower extremity intermuscular venous thrombosis after knee arthroscopy
Objective To explore the guiding value of thromboelastography (TEG) in the formulation of personalized anticoagulation regimen after knee arthroscopy. Methods A total of 50 patients who underwent knee arthroscopy in our...
Molecular mechanism of ABO bood group variation
Objective To study the relationship between ABO subtype, para-Bombay blood group and genotype, so as to explore the possible molecular mechanism of these two blood groups, and provide accurate genetic detection targets a...