EXPLORING BIOMARKERS OF ANEMIA IN NEONATES WITH GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2019, Vol 7, Issue 8
Abstract
Background: Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is the most common enzymopathy. It induces haemolytic crises with hyperbilirubinemia in newborns and a consequent anemia. Objective: In this study, we aimed to assess if anemia markers are affected in G6PD deficient newborn in the absence of oxidative attack. Methods: This is a cross-sectional descriptive study carried on in 185 infants aged 7 days and younger in southern Benin. The enzymatic activity of G6PD was assayed with Lactate Dehydrogenase (LDH) and Alkaline Phosphatase ALP) activities, Iron, Total Proteins (TP), reticulocytes levels and hemoglobin (Hb) levels. Data were analyzed with SigmaPlot Statistical Analysis Software 2014. Mean and Standard Errors on the Mean (SEM) of blood parameters were calculated. Student\'s t-test and Mann-Whitney Rank Sum test were used to ascertain difference between group characteristics. The study was approved by the national ethics committee. Results: A total of 44 newborns (23.78%) were G6PD deficient. The Minan and Adja ethnic groups were the most affected with a prevalence of 45.45% and 40.00% respectively. The mean level of TP (57.92?2.04 vs. 61.31?5.01), Iron (1.78?0.15 vs. 1.76?0.44) and the enzymatic activity level of PAL (136.76?6.69 vs. 117.33?5.04) and LDH (291.15?19.50 vs. 279.57?69.32) did not vary significantly in severe G6PD deficientneonates compared to normal. Conclusion: Hemolytic anemia biomarker are not affected in G6PD deficiency neonates.
Authors and Affiliations
Salomon E. M. Fiogbe, Casimir D. Akpovi, Julien G. A. Segbo , Fifame E. E. Kougnimon, Gratien G. Sagbo and Clement Agbangla.
Keywords
Related Articles
- EP ID EP632760
- DOI 10.21474/IJAR01/9510
- Views 51
- Downloads 0
THE IMPACT OF ORGANIZATIONAL CULTURE ON ADOPTING THE AGILE METHOD IN SERVICE PROJECTS.
The article will address one subject that most researchers hesitate or avoid tackling. Criticizing organizational culture and assessing its impact on important decisions is not a popular endeavor. The article highlights...
PERSONAL REFERENCES & PERSONAL AUTONOMY ADOLESCENTS TO GENRE CONCEPT RELATED TO EARLY CHILDHOOD MARRIAGE IN KABALUTAN ISLAND CENTRAL SULAWESI.
Adolescent acceptance of early marriage is responded positively and negatively. This is because of external factors, namely personal references or internal factors, namely personal autonomy. The GENRE program which focus...
SCIENCE PROBLEM SOLVING SKILL IN GUIDED INQUIRY LEARNING AT SCHOOL OF COFFEE PLANTATION SCHOOL AREA IN JEMBER, INDONESIA.
This research ia a comparative reaserch which aims to to examine the effect of student problem solving skills about coffee which is one of the locals (superior commodity) of the local population towards the learning with...
THE EFFECT OF BOARD DIRECTOR ON THE BOARD COUNCIL FUNCTION AND CONFIGURATION.
This paper studies the Chief Executive Of?cers (CEOs) age effect on board council function and configuration. Through utilizing a sample of the 20 largest private university in Gulf Cooperation Council (GCC). The base of...
THE INFLUENCES OF DEMENSIA ON THE FULFILLMENT OF DAILY LIVING ACTIVITY (ADL) IN ELDERLY PEOPLE
Objective: This study aimed at analyzing and then determining whether there was an effect of dementia on the fulfillment of Activity of Dayling Living (ADL) over some social institutions in 2017. This study used a non-ex...