Abstract

Gmelina arborea is an important medicament in many anti arthritic drugs in ayurvedic system. Arthritis is complex disease which not only affects the joints but also affect the quality of life of patients.   Clinical data revealed that increase levels of hyaluronidase contribute significantly to cartilage degradation. We evaluated the cartilage protective action of the plant extract   (hydro alcoholic extract Gmelina arborea) by examining its effects on the activities of pure hyaluronidase. A simple spectrophotometric method was used to assay Hyaluronidase activity and to detect the potential of extracts. Hydro-alcoholic extracts of Gmelina arborea root and bark extract showed strong inhibition of hyaluronidase activity.

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