Exploring the Role of Remote Ischemic Preconditioning in Long Term Cognitive Impairment after Global IschemiaReperfusion-Induced Vascular Dementia in Mice
Journal Title: Journal of Clinical and Medical Research - Year 2020, Vol 2, Issue 5
Abstract
Aim: The aim of the present study is to explore the neuroprotective effects of remote ischemic preconditioning in long term cognitive impairment after global cerebral ischemia induced-vascular dementia in mice. Material and methods: The mice were subjected to global cerebral ischemia by occluding the bilateral common carotid arteries for 12 minutes followed by the 24 hours of the reperfusion. The remote ischemic preconditioning stimulus was delivered in the form of 4 cycles of ischemia/reperfusion for 5 minutes each. The cerebral ischemic injury induced-long term cognitive impairment-related learning and memory alterations was assessed using morris water maze, the motor performances of the animals were evaluated using rota-rod test and neurological severity score. The cerebral infract size of the brain were quantified using triphenyltetrazolium chloride staining. Results: Global cerebral ischemia causes long term memory impairment, decreases motor performances and increases the brain infract size in animals. The delivery of remote ischemic preconditioning stimulus significantly abolished the long-term cognitive impairment and ameliorates the motor performances as well as cerebral infract size in brain. Conclusion: The remote ischemic preconditioning mediates neuro protection against global cerebral ischemic injury induced long-term cognitive impairment.
Authors and Affiliations
Diwakar Sharma, Nirmal Singh, Amteshwar Singh Jaggi*
Keywords
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- EP ID EP708409
- DOI https://doi.org/10.37191/Mapsci-2582-4333-2(5)-045
- Views 51
- Downloads 0
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