EXPOSURE TO POLYCYCLIC AROMATIC HYDROCARBONS AND NEWBORN BIOMETRIC INDICATORS
Journal Title: International Journal of Occupational Medicine and Environmental Health - Year 2010, Vol 23, Issue 4
Abstract
[b]Objectives:[/b] The aim of the study was to examine the impact of polycyclic aromatic hydrocarbons (PAH) on foetal growth. [b]Materials and Methods:[/b] The prospective Polish Mother and Child Cohort study was performed in 8 regions of Poland. The study population consisted of 449 mother-child pairs All women were interviewed three times during pregnancy (once in each trimester). 1-hydroxypyrene (1-HP) concentration in urine was chosen as the biomarker of exposure to PAH. The urine sample collected from the participant women between 20–24 weeks of pregnancy was analysed using high performance liquid chromatography (HPLC). The active and passive smoking exposure was verified by determination of saliva cotinine level using high performance liquid chromatography coupled with tandem mass spectrometry/positive electrospray ionisation (LC-ESI+MS/MS) and isotope dilution method. [b]Results: [/b]The exposure to PAH measured by 1-HP level in urine of pregnant women was significantly associated with child birth weight (β = –158.3; p = 0.01), chest circumference (β = –0.7; p = 0.02) and cephalisation index (β = 4.2; p = 0.01) after adjustment for gestational age, child gender, pregnant woman marital status, educational level, season of last menstruation period (LMP), prepregnancy body mass index (BMI), and weight gain in pregnancy. After inclusion salivary cotinine levels into the analysis, the results were not statistically significant. [b]Conclusions:[/b] Prenatal exposures to PAH adversely influence foetal development including child weight, length, head and chest circumference. Tobacco smoking is the important source of PAH. After controlling for active and passive smoking, the observed associations were not statistically significant.
Authors and Affiliations
KINGA POLAŃSKA, WOJCIECH HANKE, SŁAWOMIR BRZEŹNICKI, DANUTA LIGOCKA
Keywords
Related Articles
- EP ID EP102669
- DOI 10.2478/v10001-010-0028-1
- Views 102
- Downloads 0
Seroprevalence of anti-HAV total antibodies among workers in wastewater treatment plants
Objectives: Data on high frequency of hepatitis A virus (HAV) antibodies for wastewater treatment staff is contradictory. Literature lacks data on the seroprevalence of antibodies to HAV (anti-HAV) among workers in waste...
Influenece of the CPRmeter on angular position of elbows and generated forces during cardiopulmonary resuscitation
Objectives: It is commonly known that ergonomics in emergency medical services (EMS) is very important. Emergency medical services workers are exposed to different conditions and they should perform a variety of tasks. M...
Presence and use of automated external defibrillators in occupational setting, Belgium
Objectives: Few studies focus on out-of-hospital cardiac arrests in the occupational setting. Therefore, this study describes the presence and use of an automated external defibrillator (AED) at Belgian workplaces during...
Assessment of manual dysfunction in occupationally active women with carpal tunnel syndrome
Objectives: The aim of this study is to evaluate 2-point discrimination sense (2PD), strength and kinesthetic differentiation of strength (KDS), range of motion (ROM) and kinesthetic differentiation of movement (KDM) dys...
COMPARISON OF THE IN VITRO HEMOLYTIC EFFECTS PRODUCED BY ALKOXYACETIC ACIDS ON HUMAN AND RAT ERYTHROCYTES
[b]Objectives:[/b] The alkoxyacetic acids (AAAs) are urinary metabolites of alkoxyethanol solvents. It is well documented that these chemicals can cause acute hemolytic anemia in humans and laboratory animals. There are...