Expression Analysis of p53 and Cyclooxygenase-2 in Oral Lichen Planus
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 3
Abstract
Background: Oral lichen planus (OLP) is a chronic inflammatory disease of unknown origin. WHO classifies OLP as a potentially malignant disorder; however, the underlying mechanisms initiating development of cancer in OLP lesions have not been understood. The p53 tumor suppressor plays an important role in many tumors and an increased expression of p53 protein has been seen in OLP lesions. Cyclooxygenase-2 (COX-2) is a key enzyme for inflammatory processes and cellular proliferation, which has also been observed to over express in this chronic inflammatory condition. The aim of this study was to find the expression of p53 and COX2 in histopathologically diagnosed specimens of OLP and to explore the possible correlation between them. Method: This study was conducted on 60 histopathologically diagnosed cases of OLP and 10 normal oral mucosa specimens as controls. Immunohistochemistry was performed to find out the p53 and COX -2 protein expression. Result: The expression of p53 was positive in 80% of the cases of OLP as compared to normal oral mucosa, however, COX-2 expression was positive in 83.34%. No significant correlation was found between p53 and COX-2. Conclusion: p53 and COX-2 have shown significant increase in expression in OLP cases as compared to normal, therefore these two markers can be used for routine histopathological examination to identify OLP lesions for development of OSCC.
Authors and Affiliations
Zafar Iqbal Bhat
Keywords
Related Articles
- EP ID EP368734
- DOI -
- Views 59
- Downloads 0
Correlation of Functional Capacity and Disease Severity Indices with Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
Background: Chronic Obstructive Pulmonary Disease (COPD) reduces exercise capacity which in turn restricts patient’s ability to carry out daily activities and affects Quality Of Life (QOL). Six minute walk test is a simp...
Unlike the Textbook Triad: A Rare Case of Aicardi Syndrome
Aicardi syndrome (AS) is an X-linked inherited disorder characterized by infantile spasms, chorioretinal lacunae, and agenesis or hypogenesis of the corpus callosum. Since the description of the first case of Aicardi syn...
A Study on Dietary and Physical Modification among Gestational Diabetes Mellitus Patients
Background: Changes in dietary pattern and sedentary lifestyle increases the risk of Gestational Diabetes Mellitus that affect the fetal outcome and also increase the chances of developing type 2 diabetes mellitus in lat...
Effect of Competency Based Education on Infection Control Practices of Labour Room Nurses in Raigad district, Maharashtra
Poor infection prevention practices in labor and delivery units also cause puerperal sepsis, neonatal sepsis and other infections of childbirth. The health workers are also at risk of contracting infections in labour roo...
Serum Electrolytes and Hepatic Enzymes Level in Alcohol Withdrawal Patients with and Without Delirium Tremens - A Comparative Study
Background: Delirium Tremens (DTs) is an emergency situation with high mortality rate in alcohol withdrawal patient. Despite in an era of intensive care and advanced pharmacotherapy, the current mortality in patients wit...