Expression and Clinical Significance of Sox9 in Colorectal Carcinoma
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 8
Abstract
Colorectal cancer is the third most common cancer in men and the second in women worldwide. CRC patients usually present with chronic abdominal pain, change in bowel habits, alternating episodes of diarrhoea and constipation, rectal bleeding or blood in stool, unexplained weight loss etc. Colorectal cancers result from the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic epithelium to colonic adenocarcinoma. At least two distinct pathways have been known; APC/β catenin pathway (Wnt pathway) also known as classical adenoma –carcinoma sequence and microsatellite instability pathway. SOX9 directly regulates IGFBP-4 in the intestinal epithelium. SOX9 regulates cell lineage specification by directly regulating target genes and previous reports have shown cell proliferative and suppressive roles for SOX9. SOX9 shares 70% amino acid homology to SRY through its HMG box, the domains of which are involved in the regulation of DNA-dependent processes, such as transcription and replication. It has important functional and clinical role in tumorigenesis. The present study was carried out with the aim to demonstrate immunostaining for SOX9 in Colorectal carcinoma and its correlation with clinicopathological factors. A total of 60 cases of colorectal carcinoma were taken into study. Histological sections were reviewed and graded according to differentiation.
Authors and Affiliations
Dr Riddhi Jaiswal
Keywords
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