Expression Fas and FasL antigen protein of lymphocytes T and B in hypertrophied adenoid in children with otitis media with effusion
Journal Title: Otolaryngologia Polska - Year 2008, Vol 62, Issue 1
Abstract
Introduction. Apoptosis of lymphocytes can be induced by different factors mainly however the activation of antigen Fas (CD95) and his ligand FasL (CD95L) route. Apoptosis induced by Fas-FasL has large significance in elimination of lymphocytes T in final phase immune response designate AICD (activation induced cell death). Lymphocytes B undergo apoptosis induced by Fas-FasL in germinal center, which has special meaning in elimination of cells about low specificity and weak affinity of receptor BCR ( B-cell antigen receptor). Aim of study. The aim of this study was evaluation of percentage of apoptotic lymphocytes and expression of Fas and FasL in CD4+, CD8+, CD19+ lymphocytes in hypertrophied adenoid and hypertrophied adenoid and otitis media with effusion. Methods. CD4+ Fas+, CD8+Fas+, CD19+Fas+ CD4+ FasL+, CD8+FasL+, CD19+FasL+ cells subpopulation were identified using monoclonal antibodies and flow cytometry method. Results. The percentage of lymphocytes CD4+ Fas+, CD8+Fas+, CD19+Fas+ was higher in hypertrophied adenoid and otitis media with effusion compored to the control group. Their was no significant difference the percentage CD4+ Fas+, CD8+Fas+, CD19+Fas+ CD4+ FasL+, CD8+FasL+, CD19+FasL+ in hypertrophied adenoid and otitis media with effusion then the control group. The percentage of apoptotic lymphocytes was higher in hypertrophied adenoid and otitis media with effusion compored to the control group. Conclusions. The susceptibility the individual subpopulation of lymphocytes in hypertrophied adenoid seems to influence on change of relations of quantitative lymphocytes and upset the immunological function of tonsils which can influence on course otitis media with effusion at children.
Authors and Affiliations
Beata Żelazowska-Rutkowska, Jolanta Wysocka, Karol Ratomski, Bożena Skotnicka, Janusz Żak, Małgorzata Mrugacz
Keywords
Related Articles
- EP ID EP51407
- DOI -
- Views 96
- Downloads 0
Evaluation results of treatment polyps of nose and paranasales sinuses by endoscopic method
Introduction. This work aimed at the analysis of results of the treatment of nasal and paranasal sinus polyps by the endoscopic method. Material and methods. The tests were conducted on 142 patients, including 75 women a...
Intracranial complications from sinusitis
Introduction: Despite increasingly better diagnostic and therapeutic methods intracranial sinogenic complications, , invariably pose a direct threat to the lives of patients and a challenge for otolaryngologists. Aim: Th...
Dostęp czaszkowo-twarzowy w leczeniu guzów zatok przynosowych z zajęciem przedniego dołu czaszki
Analiza trudności we wczesnej diagnostyce audiologicznej dzieci
Wstęp: Optymalnym okresem do przeprowadzenia diagnostyki zaburzeń słuchu są pierwsze trzy miesiące życia dziecka, a odpowiednia terapia oraz wdrożenie leczenia i/lub rehabilitacji powinno być rozpoczęte przed ukończeniem...
Porównawcza ocena wyników leczenia alergicznych i niealergicznych nieżytów nosa za pomocą kriochirurgii
SUMMARY Introduction: The aim of the work was to assess the treatment efficiency in patients with allergic and non-allergic vasomotor rhinitis after cryoablation procedures. Materia! and methods: The study covered 60 pat...