Expression of Androgen Receptor in Triple Negative Breast Cancer Biopsies and Its Correlation with Prognostic Markers
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2019, Vol 8, Issue 2
Abstract
Context: Androgen receptor (AR) has been found to be associated with the occurrence and progression of breast cancer; however, their clinical significance in triple negative breast carcinoma (TNBC) cases is still a matter of debate. Aims: The present research work was done to study the expression of AR in TNBC biopsies (ER-, PR-, & HER2/neu-) by immuno-histochemistry and to correlate AR expression patterns in TNBC with Ki-67 and other prognostic markers. Settings and Design: The present cross-sectional study was conducted byDepartment of Pathology, Hind Institute of Medical Sciences, Barabanki, Uttar Pradeshfrom 2015-16. Methods and Material: ER, PR and AR negative expression were defined as <10% nuclear staining and also HER2 (2+), FISH was performed. Nuclear staining was done for estimation of Ki-67. Statistical Analysis Used: Categorialvariables were expressed as frequencies and percentages and Chi-square test was used to study the association. P value < 0.05 was considered as significant. Results: The mean age of TNBC cases was 53.8 ± 11.2 years. The most common Blooms Richardson histopathological grade found was Grade II in 35 cases (70%) followed by Grade III in 15 cases (30%). Majority of TNBC in our study group (60%) were AR positive (intermediate or strong). The AR positivity was found to be significantly associated with postmenopausal status and lymph nodes involvement. About 65% of the cases negative for AR intensity were from patients who were in pre-menopausal group. Among 80% cases with involvement of lymph node, the AR intensity was strongly positive. No significant correlation was observed between AR and Ki-67 expression. Conclusions: Although,in our study no statistically significant correlation was observedbetween AR and Ki-67 index among TNBC cases but a strong AR intensity was observed with lymph node involvement. Thus in TNBC patients, evaluation of AR status may provide additional information on prognosis and treatment.
Authors and Affiliations
Anshita Arora
Keywords
Related Articles
- EP ID EP595564
- DOI 10.21088/ijprp.2278.148X.8219.3
- Views 54
- Downloads 0
Study of p53 Gene Expression in Urinary Bladder Carcinoma: Prospective & Retrospective Study
Introduction: The present study of Urothelial carcinoma is intended to include: Retrospective hospital based observational study of paraffin section of old block and cases attending our hospital. Material Methods: The st...
Malignant and Premalignant Lesions of the Oral Cavity: A Histopathological Study in a Rural and Semi-Urban Population of India
Background: In a developing country like India, Oral cancer is a major health issue, representing the leading cause of death. Objective: Study the spectrum of premalignant and malignant lesions with grading of malignant...
Histopathological Study of Prostatic Lesions: Our Experience at a Rural Medical College, Uttar Pradesh
Introduction: Prostatism is a common disease in the geriatric age group. Benign prostatic hyperplasia and Carcinoma of the prostate are increasingly frequent with advancing age. Aim of the present cross-sectional study i...
Histopathological Patterns in Abnormal Uterine Bleeding at a Tertiary Hospital
Background: Abnormal uterine bleeding (AUB) is related with patient’s social,familial and personal life because of the considerable morbidity it causes. The aim of the study was to examine the histopathological patterns...
Role of Vitamin B12 Supplementation in Type 2 Diabetes Cases on Prolonged Metformin Therapy
Vitamin B12 is a neurotropic, water soluble vitamin and is one of the major cause of development of Diabetic peripheral neuropathy. Metformin is known to cause depletion of vitamin B12 stores resulting in its deficiency....