Expression of Autocrine Motility Factor Receptor and ECadherin in Gastric Adenocarcinoma-A Correlative study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Carcinoma of the stomach is still remained among the most common cause of cancer death worldwide. In an effort to understand interaction between force of Intercellular adhesion and its disruption by propagating cancer cells we have selected 46 caresses of Gastric adenocarcinomas. As E-cadherin (ECD) is the strongest intercellular adhesion molecule in nonmalignant Gastric mucosal epithelial cell and Autocrine motility Factor (AMF) is an established propagator of its malignant counterpart, we have studied simultaneous expression of ECD and AMFR (Autocrine motility Factor Receptor).With aid of immunohistochemical technique, strong or weak expression of ECD and AMFR was determined according to predetermined parameters .Normal Gastric mucosal cell (the control cases) strongly express ECD whereas reverse was true with AFMR. We find decrease ECD and simultaneous increase of AMFR in gastric adenocarcinomas. Furthermore, more aggressive morphologic variant showed varied expression in comparison to its less aggressive type. Diffuse type of Gastric adenocarcinoma show weak ECD (61.5% vs 40%) and more AFMR ( 53.8% vs 30%)expression in comparison to Intestinal type. Strong AMFR expression is correlated positively with increasing depth of invasive tumor. As both ECD and AMFR are involved in the pathway of tumor progression as well as development of more aggressive type of Gastric Adenocarcinomas, their simultaneous examination is necessary to evaluate biologic potential of this tumor.
Authors and Affiliations
Dr. Debashis Roy Burman, Dr. Dibyendu Goutam
Keywords
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- EP ID EP239016
- DOI 10.9790/0853-1610010915
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