Expression of chosen chemokine receptors on the Thlymphocytes in children with hypertrophied adenoids with otitis media with effusion
Journal Title: Otolaryngologia Polska - Year 2009, Vol 63, Issue 2
Abstract
Introduction: Chemokine receptors play a crucial role in the recruitment of leucocytes into inflamed tissue from secondary lymphoid organs. Aim of this study: was evaluation of the percentage Th (CD4+) lymphocytes with expression of chemokine receptors: CCR3, CCR4, and CCR5 in hypertrophied adenois tissue in children with otitis media wirh effusion. Material and methods: 36 children with otitis media with effusion and 25 children with hypertrophied adenoids were tested. Expression of chemokine receptors CCR3, CCR4 and CCR5 on T CD4 lymphocytes of hypertrophied adenoid’s tissue was estimated by fl ow cytometry method. Results: Average percentage of T CD4+ lymphocytes with expression CCR4 in hypertrophied adenoid in children group with otitis media with effusion (OME = 64,11%) was signifi cantly higher than in comparative group with hypertrophied adenoid (HA = 75,05%, p < 0,04). We showed statistically lower percentage of CD3+CD4+ cells with expression CCR3 in examinated group (OME =47,19%) than HA group (62,66%; p<0,003). Conclusion: Results suggests that intensify of humoral immunological answer in hypertrophied adenoid depends on Th2 lymphocytes with expression CCR3 and CCR4 chemokine receptors in course of infl ammatory state in middle ear.
Authors and Affiliations
Karol Ratomski, Jolanta Wysocka, Bożena Skotnicka, Edwina Kasprzycka, Beata Żelazowska-Rutkowska, Janusz Żak, Elżbieta Hassmann-Poznańska
Keywords
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