Expression of Cytokines in Vaginal Secretion of Women with Yeast Colonization
Journal Title: Microbiology Research Journal International - Year 2016, Vol 16, Issue 4
Abstract
Aim: Comparative analysis of local expression of IL-2, IL-10 and TNF-α was carried out to provide an insight to the extent and type of localized immune response associated with yeast colonization of the urogenital tract. Study Design: Descriptive Observational study. Place and Duration of the Study: University of Port Harcourt Teaching Hospital. January to June 2015. Methodology: Cytokines were assayed using standard ELISA techniques. Cytokine concentrations were compared across multiple groups by use of the Kruskal-Wallis and Dunn's posts’ tests. Results: There was a significantly elevated (p < 00.05) TNF-α concentration in women with yeast colonization (25.6 pg/ml) when compared to women with normal microbiota (22.2 pg/ml). There was also significant elevated level (p < 00.05) of average IL-10 concentrations in women with yeast infection (20.9 pg/ml) when compared to women with normal microbiota (14.8 pg/ml). However, there was no significant difference (p > 00.05) in the average IL-2 concentrations of women with yeast colonization and normal microbiota (10.4 pg/ml and 10.2 pg/ml respectively). Conclusion: The study showed a significant pro-inflammatory immune response to yeast colonization, with a minimal humoral mediated immune response and no hypersensitivity. The local expression of TNF-α and IL-10 increases with the extent of yeast cell colonization.
Authors and Affiliations
L. N. Ossai-Chidi, O. K. Obunge, C. Nnadi, A. T. O. Awopeju, M. A. Alex-Wele
Keywords
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- EP ID EP350879
- DOI 10.9734/BMRJ/2016/27438
- Views 97
- Downloads 0
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