Expression of Micro RNA 144 in sickle cell disease
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 3
Abstract
Sickle cell is a point mutation, individual homozygous Sickle disease (HbSS) shows the same genetic mutation but the severity and manifestation of this disease are extremely heterogeneous .The major pathology of sickle cell diseases is haemolysis and vaso-occlusion. This study is aim at quantifying the MiRNA144 in steady and crisis state in sickle cell diseases. D’Agostino & pearson Ormnibus normality test, Kruskal Wallis and Dunns multiple comparison test were computed on all the patients recruited. 40 HbSS patients were enrolled, 20 at steady state and 20 at crisis state, then 20 AA controls and 20 AS controls. The mean value of microRNA-144 of HbSS at crisis state was 551.80 ± 503.40 copies/5µl cDNA while HbSS at steady state was 1481 ± 2043.00 copies/5µl cDNA, the mean value of miRNA-144 of HbAA was 4.10 ±7.58 copies/5µl cDNA, while the mean value of miRNA144 of HbAS was 22.15 ± 15.49 copies/5µl cDNA. There was no statistical significant difference ( p>0.05 ) in the mean value values of miRNA144 in HbSS at crisis and steady state , there was a statistical significant difference ( P <0.001 ) in the miRNA 144 of HbSS at crisis state and HbAA , there was statistical significant difference (P < 0.001) in the miRNA144 at steady state and HbAA and HBAS. In conclusion there is no statistical significant difference between miRNA144 in sickle cell diseases
Authors and Affiliations
Swem C. A. 1 , Ukaejiofo E. O. 2 , Obeagu E. I. 3 Eluke B. 2
Keywords
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- EP ID EP563340
- DOI 10.22192/ijcrms.2018.04.03.004
- Views 127
- Downloads 0
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