EXPRESSION OF NF-ΚBMRNA IN ASTHMA RATS LUNG BASED ON THE EFFECT OF DIFFERENT TCM TREATMENT
Journal Title: Asian Pacific Journal of Microbiology Research (APJMR) - Year 2017, Vol 1, Issue 1
Abstract
To detect expression of NF-κB gene in the asthmatic rats lung tissue to explore the effect of NF-κB in asthma rats airway remodeling based on Real-time quantitative PCR. Then to research the effect of different TCM interventions for its role. Asthma rat models were prepared by injecting ovalbumin (OVA) into the abdominal cavity and inhalation of aerosol, and intervented by the different TCM treatment methods，example for body resistance-strengthening, lung-diffusing, lung-diffusing and body resistance-strengening. Then detected expression of NF-κB gene in the asthmatic rats lung tissue based on Real-time quantitative PCR. And compared lung coefficient between the rats in each group. The results showed that the three prescriptions can all reduce the expression of NF-ΚB in the lung tissue, there is statistical significant difference between model group and lung-diffusing and lung-diffusting and body resistance-strengthening group. The three treatment methods can reduce the lung coefficient. NF-κBmRNA is Gene NF-κB in airway remodeling in asthmatic rats has important value and different TCM treatment is effect to it. This is consistent with TCM theory understanding to asthma. The pathogenesis of asthma is deficiency of healthy Qi and exuberance of evils, then the treatment principles should strengthen healthy Qi to remove toxic substance.
Authors and Affiliations
Li Xueliang, Xu Zhaoxia, Qian Peng, Cheng Lijun, Yan Haixia, Guo Rui, Wang Yiqin
Keywords
Related Articles
- EP ID EP403980
- DOI 10.26480/ajmr.01.2017.01.04
- Views 57
- Downloads 0
DESIGN OF A PAINTING ROBOT WITH HOLLOW NON-SPHERICAL WRIST
Painting robot is one of the key systems for automobile manufacturing, thus its structural design and safety check have significant value in industrial circles. To facilitate the layout of pipeline and reduce the bending...
THE EFFECT OF AEROBIC EXERCISE ON EXPRESSIVE LEVEL OF VCAM-1 AT APOE-DEFICIENT MOUSE AORTA
ApoE-deficient mice was used as AS model to approach the effect of aerobic exercise on the expressive level of VCAM-1 on apoE-deficient mouse aorta. METHODS: 20 apoE-deficient mice were randomly divided into control grou...
N-METHYLENE PHOSPHONIC CHITOSAN: A NOVEL SELF- ASSEMBLED TEMPLATE FOR ENAMEL REMINERALIZATION
To evaluate the feasibility of phosphonic chitosan membrane in guiding enamel remineralization. We design a organic molecules model to induced the crystallization of hydroxyapatite with 3D-structure in a controllable way...
PREVALENCE AND IDENTIFICATION OF UROPATHOGENS IN EASTERN NEPAL AND UNDERSTANDING THEIR ANTIBIOGRAM DUE TO MULTIDRUG RESISTANCE AND ESBL
This study was basically aimed at identifying the diversity of uropathogens; their drug response like multi-drug resistance (MDR) or extended spectrum β-lactamase (ESBL); and the evaluation of empirical treatment. Betwee...
DEVELOPMENT OF AN ECONOMIC TENSILE AND TORSION TESTING MACHINE FOR WIRES
The tensile and torsion properties of materials are extremely important in the design, analysis and manufacture of a wide variety of products and components which are loaded primarily in tensile and torsion loads. A bulk...