EXPRESSION OF SURVIVIN AND p53 IN BREAST CANCER
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 7
Abstract
BACKGROUND Survivin, a novel inhibitor of apoptosis, that inhibits caspases and blocks cell death, is highly expressed in most cancers. Many studies have indicated that aberrant expression of Survivin is associated with poor prognosis, drug and radiation resistance. The p53 gene is a tumor suppressor gene. The significance of p53 detection is that p53 mutation is linked with chemo resistance and transformation to more aggressive disease in a large number of tumor cell types. Aim- To study the expression of Survivin and mutant p53 in breast cancer and its effect on clinical outcome in breast cancer patients. MATERIALS AND METHODS It is a descriptive study on 75 patients. Paraffin embedded tissue samples from 34 untreated female patients with Invasive ductal carcinoma and 41 female patients with fibroadenoma were used. Expression of Survivin and mutant p53 was evaluated using immunohistochemistry staining method. RESULTS In our study, 79.4% cases of invasive ductal carcinomas and 37.5% cases of fibroadenoma stained positive of survivin. While 85% cases of invasive ductal carcinomas and 50% cases of fibroadenoma stained positive for p53. CONCLUSION Increased expression of Survivin and mutant p53 in IDC patients suggest that Survivin and p53 are likely to contribute significantly to apoptosis resistance and may serve as therapeutic target that could increase the effectiveness of conventional breast cancer therapy.
Authors and Affiliations
Nath Dwijendra, Agrawal Pallavi, Singh Arun, Rawat Niharika
Keywords
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- EP ID EP399147
- DOI 10.14260/jemds/2018/201
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