Expression of the Coxsackie-Adeno-Virus Receptor on Pancreatic β-Cells of Rat and Human Origin
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 3
Abstract
Abstract: Type 1 diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells in the pancreatic islets of Langerhans. This process is induced in genetically susceptible individuals by some, still not known, environmental factors. These environmental factors are believed to be enterovirus infections, which have a significant role in initiation and development of the disease. The first requirement for infection is the presence of a virus receptor on the host cell. The coxsackievirus and adenovirus receptor (CAR) is a common receptor for all the coxsackievirus B serotypes, which is a member of the enterovirus family. In this project my aim was to investigate the expression of human CAR mRNA in human pancreatic islet cells, and to investigate the expression of rat CAR mRNA in rat cell line (RINm5F) cultured as monolayer and free foating cell clusters (RCC). The investigation was done by two methods, one that analyzed presence of the CAR gene and one that analyzed the presence of the CAR protein. Results show that the receptor protein CAR was expressed in pancreatic beta-cells of rat and human.
Authors and Affiliations
Asma Elshebani, Anna-Karin Berg, Gun frisk
Keywords
Related Articles
- EP ID EP475850
- DOI -
- Views 50
- Downloads 0
Study of Hodgkin Lymphoma with Special Reference to NLPHL in A Tertiary Care Hospital in Eastern India
Abstract:Hodgkin lymphoma is one of the most common lymphomas in the developed world. There is a great importance of histological sub classification of Hodgkin lymphoma so far prognostic importance is concerned. Moreove...
Assessment of Knowledge and Practice Regarding Breast Feeding Amongst the Lactating Mother
The useful impact of breastfeeding for both mother and infant are outstanding. In spite of its known points of interest, breastfeeding rates are low world over. Substantial number of components influences breastfeeding....
A Survey of the Prevalence of Hepatitis B and Hepatitis C Antibodies amongst HIV Positive Patients in Tertiary Health Institution in South Eastern Nigeria
Human immunodeficiency virus is a major pandemic in Nigeria and the growing prevalence of hepatitis of Hepatitis B and C admix infection in on increasing measure. A survey on the prevalence of hepatitis B and C amongst H...
Surgery for Elephantiasis of the lower limbs Dieng P. A, Diatta S, Ba P.O, Ba P.S, Gaye M, Diop M. S, Sow N. F, Fall M. L, Ciss A.G, Ndiaye A, Ndiaye M
Untreated acute lymphedema leads to elephantiasis. Anatomical deformities cause disability and psychological issues. Several types of treatment have been used by practicians since the Antiquity. The aim of this study is...
Pregnancy with Fibroids and Its Obstetric Complications
Abstract: Women with uterine fibroids are more likely have pregnancies complicated by fetal malpresentation, preterm birth, and preterm premature rupture of membranes (PPROM), placenta previa, placental abruption, cesare...