Expressions of HPV 16-E6 in esophageal carcinoma and its clinical significance
Journal Title: Journal of Advances in Internal Medicine - Year 2015, Vol 4, Issue 2
Abstract
Aim: The aim of the study was to explore the association between HPV16-E6 protein and esophageal squamous cell carcinoma. Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue. Result: The expressions of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had a significant correlation with invasive depth (P<0.05), but not with the patient age, lymph node metastasis and tumor size (P>0.05). Conclusion: HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma.
Authors and Affiliations
Xing Zhao*| Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China, Rajina Sahi| B. P. Koirala Memorial Cancer Hospital, Nepal., Yu-Yang Zhao| Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China, Jun Wang| Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China, Chun- Hui Li| Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China
Keywords
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- EP ID EP4799
- DOI http://dx.doi.org/10.3126/jaim.v4i2.16897
- Views 460
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