Extended Adjuvant Endocrine Therapy After Breast Cancer: ―Longer Is Better‖
Journal Title: International Journal of Innovative Research in Medical Science - Year 2016, Vol 1, Issue 8
Abstract
Recent evidence supports the use of extended adjuvant endocrine therapy (EAET) with either Tamoxifen (TMX) or an Aromatase Inhibitor (AI) after five years of initial adjuvant TMX to reduce BC recurrence and mortality in women with hormone-receptor positive early-stage breast cancer. This manuscript wants to give a brief overview of published data and ongoing studies concerning extended adjuvant endocrine therapy. Premenopausal women should be treated with 10 years of Tamoxifen. Current strategies for postmenopausal women include initial adjuvant AI therapy, sequential AI therapy after 2 to 3 years of tamoxifen, or extended AI use after 5 years of TMX. However, data from trials looking at prolonged AI therapy beyond 5 years are required to determine the optimal total duration of AI therapy. In cases of recommending extended endocrine therapy with AI, Letrozole is first line treatment; Exemestane and Anastrozole still require research. Future studies are required; emphasis should be laid on who should use which drug, and for how long.
Authors and Affiliations
Begoña Díaz de la Noval
Keywords
Related Articles
- EP ID EP181338
- DOI -
- Views 111
- Downloads 0
Knowledge and Practice of the Use of Eye Make-Up and Its Possible Effect on Ocular Dryness among Females in Saudi University
Introduction: Several studies report that use of eye cosmetics can lead to multiple complication such as tarsal conjunctival pigmentation and posterior blepharitis by initial migration of cosmetics product material from...
WOUND HEALING PROPERTIES OF SYMPLOCOS RACEMOSA
India has a rich variety of flora that is widely distributed throughout the country. Herbal medicines have been the basis of treatment and cure for various diseases and physiological conditions in traditional methods pra...
Risk of Developing Polycystic Ovarian Syndrome- Adolescent Girls
Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders in women of fertile age, affecting 5-10% of the female population. Polycystic ovarian syndrome endocrine disturbance-affecting...
A Study on Prevalence of Pterygium at Sree Mookambika Institute of Medical Sciences
Background: Pterygium is a triangular fold of conjunctiva over cornea. Pterygium is more common in elderly male doing outdoor work. Risk factors are increasing age, male gender, outdoor occupation with ultraviolet (UV) l...
A Rare Malignancy of Para nasal Region; Osteosarcoma
In the practice of otorhinolaryngology mass in nasal cavity is often seen. According to other regions, malign tumors of the paranasal region and nasal cavity are very rare. Osteosarcomas constitute 0.5-1% of all tumors i...