Extensive Acanthosis Nigricans: A Clue to an Asymptomatic, Undiagnosed Malignancy
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 2
Abstract
Acanthosis Nigricans (AN) is a symmetrical, hyper pigmented velvety cutaneous thickening that can occur on any part of the body, but characteristically affects the axillae, nape and side of the neck, groin, antecubital and popliteal surfaces and umbilical area. Acanthosis nigricans is associated with both benign and malignant conditions. The majority (80%) are either idiopathic or associated with benign conditions such as obesity, insulin resistance, and congenital syndromes. Different tumors have been described with malignant acanthosis nigricans with adenocarcinoma being the commonest type, of which 70-90% is intra-abdominal out of which 55-61% are gastric adenocarcinomas. Malignant AN secondary to an internal malignancy is of sudden onset and rapidly progressive and pruritic, but is otherwise clinically indistinguishable from benign AN. We report a case of extensive acanthosis nigricans with an asymptomatic, undiagnosed adenocarcinoma stomach.
Authors and Affiliations
Dr. Ghanshyam Kumar Verma
Keywords
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