Extra-Skeletal and Endocrine Functions and Toxicity of Vitamin D
Journal Title: Journal of Endocrinology and Diabetes - Year 2016, Vol 3, Issue 3
Abstract
During the past 15 years, the knowledge related to vitamin D has markedly expanded, especially with reference to the hormonal and extra-skeletal effects of vitamin D. The understanding of the biological and physiological functions of 25-hydroxyvitamin D [25(OH)D] and its active hormone, 1,25-dihydroxyvitamin D [1,25(OH)2D] in humans has expanded significantly. The serum 25(OH)D level is the best indicator of vitamin D status. However, in certain groups of people, such as those who are overweight or obese or have type 2 diabetes or metabolic syndrome, the serum 25(OH)D levels may not reflect accurately, the storage amounts of vitamin D in the body. The 1,25 (OH)2D level, on the other hand, is not a marker for vitamin D status and thus, should not be measured routinely. The parent (basic) form of vitamin D (not analogs) is the choice for suppleme-ntation. Vitamin D analogs, including activated forms, should be reserved for those, whose bodies cannot generate active vitamin D compounds because of end-organ failure, such as liver or kidney disease.
Authors and Affiliations
Sunil Wimalawansa
Keywords
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- EP ID EP333672
- DOI 10.15226/2374-6890/3/3/00152
- Views 102
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