EXTRACTION AND CHARACTERIZATION OF NOVEL BIOADHESANT BIOMATERIAL OBTAINED FROM THE PHASEOLUS VULGARIS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 11
Abstract
Objective: The objective of the present study was to isolate bioadhesive biomaterial from the pulp of Phaseolus vulgaris and further characterization includes preliminary phytochemical screening, physicochemical parameter micromeritic properties, spectral analysis (like NMR, X-Ray diffraction, DSC and IR spectroscopy) and acute toxicity study. The work also emphasizes to evaluate the mucoadhesive and in built properties of isolated biopolymer.Methods: Phaseolus vulgaris biopolymer was obtained using non solvent addition method. Pharmacopoeial procedures were used to study the micromeritic properties, solubility, organoleptic properties, pH, viscosity, swelling index and surface characteristics of isolated biopolymer. The mucoadhesive property was determined by Shear stress method, falling sphere method and rotating basket method and data obtained were compared with standard.Results: The result showed that isolated biomaterial exhibited good flow behavior and pH was found 5.6 showed that this can be used in oral formulations without any irritation. SEM analysis suggests that the biomaterial has irregular particle size and XRD pattern of the biopolymer indicated a completely amorphous structure. The formation of hydrogen bond by natural bioadhesive agent with nasal mucosa was confirmed by FTIR spectra showing carboxyl and hydroxyl groups further mucoadhesive assessment suggest that the isolated biomaterial exhibited polymeric characteristics with promising inbuilt mucoadhesive property.Conclusion: The research study revealed that the biomaterial isolated from pulp of Phaseolus vulgaris exhibited a promishing potent natural mucoadhesive property and may be used to develop mucoadhesive transmucosal drug delivery systems.Â
Authors and Affiliations
Singh A. K. , Singh A. , Satheesh Madhav Nv
Keywords
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