EXTRACTION OF DRUGS FROM BIOLOGICAL MATERIALS SUCH AS VISCERA, BLOOD, URINE AND VITREOUS HUMOUR
Journal Title: International Journal of Medical Laboratory Research - Year 2017, Vol 2, Issue 1
Abstract
Sample preparation is a basic step before any chemical or instrumental analysis. Liquidliquid extraction is one of the basic steps for extraction of drug from any biological matrix such as blood, vitreous humour, urine etc. Among the highly sophisticated extraction procedures like solid phase extraction (SPE), solid phase micro extraction (SPME), liquid phase extraction (LPE), liquid phase micro extraction (LPME) and distillation, liquid-liquid is still the basic preferred method. The paper explains the basic extraction procedure for extraction of acidic, basic and neutral drugs in variety of biological matrix. Other techniques have disadvantage of being costly because it requires specific infrastructure; chemicals of high purity and expertise while handling. The advantage of using liquid –liquid extraction over other procedures is that it can be attempted with basic laboratory setup.
Authors and Affiliations
AK JAISWAL, Pallavi Choudhary, Surender . , T MILLO
Keywords
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