EXTRACTION, PURIFICATION AND PHYSICOCHEMICAL EVALUATION OF MUCILAGE OF CHRYSOPHYLLUM LANCEOLATUM (BLUME) DC FRUITS: AN INVESTIGATION FOR BIOADHESIVE PROPERTY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 2
Abstract
Objective: The objective of the present investigation is to extract, purify and characterize the physicochemical properties of the mucilage obtained from the fruits of Chrysophyllum lanceolatum (Blume) DC and also to evaluate the bioadhesiveness of Chrysophyllum lanceolatum Mucilage (CLM) to be used as the biodegradable mucoadhesive agent.Methods: The mucilage was extracted, purified and identified by the methods as described in the official books. Purified CLM was characterized for physicochemical properties, swelling capacity, loss on drying and flow properties. The CLM was further characterized by Fourier Transform Infrared (FTIR) spectroscopy, Differential Scanning Calorimetry (DSC) and High-Performance Liquid Chromatography (HPLC). The mucoadhesivity of the mucilage was assessed by shear stress method and falling sphere method using goat intestine as mucosal substrate and the results were compared with Hydroxy Propyl Methyl Cellulose (HPMC) and Carbopol 934P (CP). The acute oral toxicity study was also conducted in Swiss Albino mice.Results: The nature of the CLM is confirmed as polysaccharide from the experimental data. The physicochemical property and toxicity study also shows its acceptability as bioadhesive excipient. The bioadhesive test of CLM showed a good adhesive strength to the biological membrane.Conclusion: The present investigation showed better bioadhesive property of the isolated mucilage and hence may provide an alternative to conventional synthetic/semi-synthetic mucoadhesive agents.Keywords: Chrysophyllum lanceolatum, Mucilage, Extraction, Physicochemical, Bioadhesivity, Mucosal.
Authors and Affiliations
Amal Kumar Boruah, Lila Kanta Nath
Keywords
Related Articles
- EP ID EP577886
- DOI -
- Views 46
- Downloads 0
CEREBROPROTEIN HYDROLYSATE INDUCED SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS): A CASE REPORT
Cerebroprotein hydrolysate is a newer pharmacological neurotropic agent and considered as a promising therapeutic agent for dementia, Alzheimer’s disease, traumatic brain injury and acute ischaemic stroke. Studies reve...
SOLID LIPID NANOPARTICLES AND NANOSTRUCTURED LIPID CARRIERS OF TOLNAFTATE: DESIGN, OPTIMIZATION AND IN-VITRO EVALUATION
Objective: The target of our work is the preparation of tolnaftate (TOL) loaded solid lipid nanoparticles (SLNs) as well as nanostructured lipid carriers (NLCs).Methods: The high shear homogenization method was chosen fo...
VALIDATED STABILITY-INDICATING RP-HPLC ASSAY METHOD FOR AZATHIOPRINE IN PHARMACEUTICAL DOSAGE FORM ACCORDING TO ICH GUIDELINES
Objective: A simple, sensitive, precise and accurate stability-indicating HPLC method has been developed and validated for determination of Azathioprine in bulk drug and in pharmaceutical dosage form in the presence of d...
CULTURING AND SPAWNING STRATEGIES FOR CULTIVATION OF GANODERMA LUCIDUM (CURTIS) P. KARST
Objective: To access the vegetative growth of Ganoderma lucidum on ten solid media and four liquid media. Spawn development on different grains viz., wheat, barley, maize, soybean and pearl millet was also assessed for l...
NANOPRECIPITATION TECHNIQUE FOR PREPARATION OF STERICALLY STABILIZED RISPERIDONE NANOSUSPENSION: IN VITRO AND IN VIVO STUDY
Objective: Risperidone is an atypical antipsychotic drug used to treat schizophrenia; however it suffers from a poor aqueous solubility, which delays its onset of action. Therefore, the purpose of the present study is to...