Extralipid effects of micronized fenofibrate in dyslipidemic patients.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 5
Abstract
The aim of this study was to evaluate the levels of lipid and extralipid parameters in patients with atherogenic dyslipidemia. We investigated the lipid-lowering therapeutic efficacy of fenofibrate and its extralipid influence on oxidized low-density lipoprotein (oxLDL), C-reactive protein (CRP), fibrinogen, factor VII and plasminogen activator type 1 (PAI-1) during 1-month treatment. Fourteen individuals with HLPIIb were treated with micronized fenofibrate (267 mg/d) for 1 month. The control group included twelve volunteers. Lipidograms were determined with enzymatic kits. ELISA method was used to measure oxLDL and PAI-1. Plasma CRP levels were measured spectrophotometrically. Fibrinogen and factor VII serum levels were evaluated with automatic coagulometer. After 1-month therapy with micronized fenofibrate, we observed a significant reduction of total cholesterol (TC) (277.2 to 217.8 mg/dl, p
Authors and Affiliations
Bogusław Okopień, Maciej Haberka, Andrzej Madej, Dariusz Belowski, Krzysztof Labuzek, Robert Krysiak, Marek Zieliński, Marcin Basiak, Zbigniew Herman
Keywords
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