FACTORS AFFECTING MORBIDITY AND MORTALITY OF ACUTE KIDNEY INJURY IN NEWBORNS
Journal Title: Kocatepe Medical Journal - Year 2024, Vol 25, Issue 4
Abstract
OBJECTIVE: Acute kidney injury is one of the serious problems in Neonatal Intensive Care Units. Our study was aimed to evaluate the incidence, risk factors, primary diagnoses, treatments with early prognosis, and mortality of acute kidney injury in the neonatal intensive care units. MATERIAL AND METHODS: Hospitalized newborns who had been diagnosed with acute kidney injury in neonatal intensive care units between January 1, 2013, and December 31, 2016, were included in the study as the acute kidney injury group. Two hospitalized newborns without acute kidney injury for each acute kidney injury patient were included in the study as a control group. The diagnosis of acute kidney injury was made with serum creatinine >1.5mg/dl and/or a two-fold increase between measurements. RESULTS: Acute kidney injury was detected in 201 (2.7%) of 7418 patients hospitalized in the neonatal intensive care units during the study. Of these, 42.3% were preterm. Prerenal acute kidney injury was detected in 92.5% (186). Of these, 57.5% were oligo-anuric, and 109 (54.2%) patients died. Renal replacement therapy was required in 49 (24.5%) patients. Critical congenital heart disease (65;32.3%), hypoxic ischemic encephalopathy (36;17.9%), prematurity (23;11.4%), sepsis (21;10.4%) and dehydration (17;8.5%) were the most common causes of acute kidney injury. Liver function test abnormality, amphotericin-B, vancomycin, aminoglycoside use, seizures, presence of proteinuria, and prematurity were the independent risk factors in the development of acute kidney injury. Dopamine use and renal replacement therapy were determined as independent risk factors in acute kidney injury mortality. CONCLUSIONS: Acute kidney injury in newborns was mostly prerenal. It should not be forgotten that acute kidney injury may develop during the follow-up of newborns requiring intensive care, and the risks should be carefully evaluated, closely monitored, nephrotoxic drugs should be used carefully, and when acute kidney injury is detected, appropriate treatment should be started without delay
Authors and Affiliations
Songül TOMAR GÜNEYSU, Ayşegül ZENCİROĞLU, Mehmet BÜLBÜL
Keywords
Related Articles
- EP ID EP759928
- DOI https://doi.org/10.18229/kocatepetip.1414458
- Views 15
- Downloads 0
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