Factors associated with oxygenation improvement in children with ARDS
Journal Title: Paediatrica Indonesiana - Year 2014, Vol 54, Issue 1
Abstract
Background In pediatric patients, acute respiratory distresssyndrome (ARDS) has a high mortality rate of approximately25%. In surviving children, ARDS may result in sequelae, suchas restrictive or obstructive lung dysfunction, muscle weaknessand hypotrophy, as well as psychiatric, intelligence, and memoryproblems.Objective To identify prognostic factors related to oxygenationimprovement in children with ARDS.Methods We conducted a prospective cohort study in the pediatricintensive care unit (PICU) ofSardjito Hospital, Yogyakarta.We included 20 children aged 29 days to 18 years who fulfilled theARDS criteria. They underwent lung recruitment maneuver for1 hour. Logistic regression analysis was used to assess for possibleassociations between potential prognostic factors and oxygenationimprovement.Results None of the subjec ts had significant hemodynamicchanges or hypercapnea during lung recruitment. Two prognosticfactors from our univariate analysis, namely type of ARDS (RR0.17; 95% CI 0.023 to 1.23; P= 0.079) and severity of ARDS(RR 0.74; 95% CI 0.007 to 0.84) , were analyzed by multivariatelogression test. However, the results were not statisticallysignificant for type of ARDS (RR 0.33; 95% CI0.009 to 1.41) orseverity of ARDS (RR 0.11; 95%CI 0.009-3.25).Conclusion We do not identify any prognostic factors, includingtype and severity of ARDS, associated with oxygenationimprovement in children with ARDS.
Authors and Affiliations
Abdul Chairy, Nurnaningsih Nurnaningsih, Endy Prawirohartono
Liver iron overload and hepatic function in children with thalassemia major
Background Routine blood transfusions and increased intestinal iron absorption lead to iron accumulation in various organs, especially the liver. To date, T2-star magnetic resonance imaging (T2*MRI) is a valuable tool to...
Albendazole alone vs. albendazole and diethylcarbamazine combination therapy for trichuriasis
Background Trichuris trichiura is one of the most commonsoil-transmitted helminths, estimated to infect l billion peopleworldwide. Several studies have compared the efficacies ofalbendazole and diethylcarbamazine, but th...
Ventricular function and high-sensitivity cardiac troponin T in preterm infants with neonatal sepsis
Background Hemodynamic instability in sepsis, especially in the neonatal population, is one of the leading causes of death in hospitalized infants. The major contribution for heart dysfunction in neonatal sepsis is the m...
The role of genetic variation in TCF7L2 and KCNJ11, dietary intake, and physical activity on fasting plasma glucagon-like peptide-1 in male adolescents
Background Transcription factor 7-like 2 (TCF7L2) and potassium voltage-gated channel subfamily j member 11 (KCNJ11) gene polymorphisms have been associated with type 2 diabetes mellitus (T2DM) via regulation of insulin...
Risk factors of soil-transmitted helminth infection among elementary school students
Background Helminth infection remains a health problem, especially in school-aged children. Mass eradication programs with a single dose of anti-helminthic drugs were employed by the local government in some endemic area...