Factors Associated with Platelet Transfusions in Neonates Admitted in Intensive Care Unit in a Tertiary Care Centre
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 6
Abstract
Introduction: Neonatal thrombocytopenia (TP) is a commonly encountered problem in intensive care unit during hospital stay and platelet transfusion remains a mainstay of treatment. No study has clear data on the prevalence, causes of TP and effect of platelet transfusions in neonates. Present study was undertaken to investigate the cause for neonatal TP and transfusion practice in our institute. This would be helpful in improving guidelines and thereby reducing unnecessary transfusions and multiple donor exposures. Material and methods: 220 neonates who received platelet transfusions are analyzed prospectively during the study period of 24 months. Both neonatal and maternal factors which leads to neonatal TP was evaluated and indication for platelet transfusion was analyzed. Results: Low birth weight (74.5%), preterm babies (64.5%), pregnancy induced hypertension (PIH) (34.5%), maternal infections (28.2%) are major factors which contributed to the development of neonatal TP. 58.2% of neonates received single (128/220) and 41.8% received multiple platelet transfusions (92/220). Multiple platelet transfusions were more in necrotizing enterocolitis (NEC) (‘p’ value=0.010), intrauterine growth retardation (IUGR) (‘p’ value=0.026), hospital stay (‘p’ value=0.001), maternal infection (‘p’ value=0.003) and gestational diabetes mellitus (‘p’ value=0.002) and neonates belongs to severe and very severe (‘p’=0.001) TP categories. Conclusion: Single or multiple neonatal and maternal factors were involved in causing neonatal TP which in turn led to platelet transfusions. Most of the neonates in our study had bleeding manifestations and received platelet transfusions within 1 to 5 days of birth and mortality was higher with neonates who receives multiple transfusion.
Authors and Affiliations
Ramanathan T, Maya Devi S, K. C Usha
Keywords
Related Articles
- EP ID EP427524
- DOI -
- Views 98
- Downloads 0
Low Birth Weight Babies- Risk Factors and Complications: A Clinical Study
Introduction: Birth weight is important criterion for determining the neonatal and infant survival. Low Birth Weight (LBW) indicates socio-economic conditions and indirectly measures the health of the mother and the chil...
Anemia as Co-Morbidity in COPD: Comparative Study of Oxidant Anti-Oxidant Imbalance in Anemic and Non Anemic COPD Patients
Introduction: COPD is slowly progressing chronic airway disease. It is known to be associated with co morbidities. Anemia is associated with chronic illnesses. Inflammation, oxidative stress and physical inactivity in CO...
A Study of Sensorineural Hearing Loss in Chronic Suppurative Otitis Media Patients - On use of Topical Ototoxic Ear Drops
Introduction: The hearing impairment in patients with CSOM has generally been observed to be of conductive type and less of sensorineural type. Since long attempts have been made to establish relationship of hearing loss...
Use of Conjunctival Vessel Width for Assessment of Severity of Retinopathy in Type-2 Diabetes Mellitus Patients
Introduction: Diabetes mellitus is defined as a metabolic disorder of multiple etiologies characterized by chronic hyperglycaemia with disturbances of carbohydrate, protein and fat metabolism resulting from defects in in...
Comparative Evaluation of Intrathecal Administration of Isobaric Levobupivcaine (0.5%) and Isobaric Ropivacaine (0.75%) in Patients Undergoing Lower Limb Surgeries
Introduction: Bupivacaine available as a recemic mixture of its enantiomers dextro and levo bupivacaine has been the gold standard for intrathecal use in spinal anesthesia. Levo bupivacaine and Ropivacaine are the two re...