FAST DISSOLVING TABLETS: AN UPDATE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 6
Abstract
Fast dissolving tablets are dissolving rapidly in the saliva without the need for water. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-dissolving tablets. Other ingredients to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate. Fast or mouth dissolving tablets have been formulated for pediatric, geriatric, and bedridden patients and for active patients who are busy and traveling and may not have access to water. Fast dissolving tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. This article describes various formulations and technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. In this review describes in detail about FDT technologies based on lyophilization, molding, sublimation, spray drying, mass extrusion and direct compression. Several techniques have been developed in the recent past, to improve the disintegration quality of these delicate dosage forms without affecting their integrity. This article focuses on the technologies available and the advances made so far in the field of fabrication of fast dissolving tablets. Apart from the conventional methods of fabrication, this review also provides the detailed concept of some unique patented technologies like Zydis, Orasolv, Durasolv, Flashtab, Flash dose and Wowtab, Lyoc, Pharmaburst technology, Frosta technology, OraQuick, Quick-Dis Technology, Sheaform Technology, Ceform Technology, Nano technology, Advatab.
Authors and Affiliations
Bikshapathi Darna , Saikrishna Kandikonda , Ashok Uppuluru , Sabitha Gade , Saikumar Bhupathi
Keywords
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