Fasting C Peptide Correlated with Fasting Insulin and Post Glucose Load C Peptides in Young Adults but the C Peptides could not be Partitioned Into Groups with and without Family History of Type 2 Diabetes Mellitus
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Family history of type 2 diabetes (FH) caused hyperinsulinemia. Fasting insulin was found to correlate with post-glucose load oral glucose tolerance test (OGTT) insulin and these insulin groups could be partitioned according to absence or presence FH. In this studty, correlation of fasting C peptide with OGTT C peptide, and with fasting insulin and triglycerides in young non diabetic adults were analysed. Influence of FH on fasting and OGTT C peptide groups were also studied. Material and Methods: Participants of this observational cross sectional study, aged 18 to 25 years from rural Central Kerala, have decreased influence of age, growth phase and environment. Clinical and biochemical evaluation of participants were done with cut-off levels of quantitative biochemical variables fixed to include effects of type 2 diabetes mellitus, but excluded other secondary clinical influences (n = 80). When the data had Gaussian distribution with equality of variances in the groups compared, parametric methods were used for analysis. Otherwise, non parametric methods were used. Results: Fasting C peptide correlated well with OGTT C peptide, fasting insulin and triglycerides. Correlations were better with 30 minute OGTT C peptide than with 60 and 120 minute OGTT C peptides. But unlike insulin, fasting and OGTT C peptide groups could not be partitioned according to FH. Conclusion: Difficulty in partitioning C peptide may be due to confounding of increased insulin secretion from insulin resistance by the decreased insulin secretion from beta cell dysfunction, resulting in absence of increase in C peptide in participants with FH.
Authors and Affiliations
Saritha Francis, Sindu Padinjareveedu C, Nesheera K K, Jose Jacob
Keywords
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