Fasting Insulin is Better Partitioned according to Family History of Type 2 Diabetes Mellitus than Post Glucose Load Insulin of Oral Glucose Tolerance Test in Young Adults
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 5
Abstract
Introduction: Hyperinsulinemia is contributed by insulin resistance, hepatic insulin uptake, insulin secretion and rate of insulin degradation. Family history of type 2 diabetes mellitus has been reported to cause hyperinsulinemia. Aim: Correlation of fasting insulin with post glucose load Oral Glucose Tolerance Test (OGTT) insulin in young adults and their partitioning according to family history of type 2 diabetes. Materials and Methods: In this observational cross-sectional study, clinical evaluation and biochemical assays of insulin and diabetes related parameters, and secondary clinical influences on type 2 diabetes in volunteers were done for inclusion as participants (n=90) or their exclusion. Cut off levels of quantitative biochemical variables were fixed such that they included the effects of insulin resistance, but excluded other secondary clinical influences. Distribution was analysed by Shapiro-Wilk test; equality of variances by Levene’s test; Log10 transformations for conversion of groups to Gaussian distribution and for equality of variances in the groups compared. When the groups compared had Gaussian distribution and there was equality of variance, parametric methods were used. Otherwise, non parametric methods were used. Results: Fasting insulin was correlating significantly with 30, 60 and 120 minute OGTT insulin showing that hyperinsulinemia in the fasting state was related to hyperinsulinemia in the post glucose load states. When fasting and post glucose load OGTT insulin were partitioned into those without and with family history of type 2 diabetes, maximum difference was seen in fasting insulin (p<0.001), followed by 120 (p=0.001) and 60 (p= 0.002) minute OGTT insulin. The 30 minute insulin could not be partitioned (p=0.574). Conclusion: Fasting, 60 and 120 minute OGTT insulin can be partitioned according to family history of type 2 diabetes, demonstrating stratification and heterogeneity in the insulin sample. Of these, fasting insulin was better partitioned and could be used for baseline reference interval calculations.
Authors and Affiliations
Saritha francis, sindhu padinjareveedu chandran, kk nesheera, jose jacob
Keywords
Related Articles
- EP ID EP341184
- DOI 10.7860/JCDR/2017/27684.9910
- Views 76
- Downloads 0
Quality of Working Life among Pharmacists in Vietnam: A Preliminary Study using an Internet-Based Survey
ABSTRACT Introduction: The Quality of Working Life (QWL) is an important factor for achieving high-performance effectiveness from workers. Despite the importance of studying QWL to enhance worker satisfaction and perform...
Large Isolated Major Aortopulmonary Collateral Artery Causing Severe Pulmonary Hypertension in an Infant: A Rare and Challenging Diagnosis
Major Aortopulmonary Collateral Artery (MAPCA) as an isolated congenital anomaly, without evidence of any structural heart disease, is a very rare observation. Previously published reports indicate that symptomatic infan...
Compliance to Antihypertensive Therapy and its Predictors: A Cross-sectional Study in Western Coastal Region of India
Abstract Introduction: Hypertension (HTN) is a chronic Cardiovascular Disease (CVD) characterised by persistently raised Blood Pressure (BP >140/90 mmHg), leading to various complications and currently causing the highes...
Assessment of Knack of Clinical Staphylococcus aureus Isolates for the Biofilm Formation and Presence of icaABCD Family Genes
ABSTRACT Introduction: Superbug known as Staphylococcus aureus possess a tendency to form biofilm, which has a significant role in causing infection and abating host defense response. Amongst many mechanisms, biofilm for...
Spindle Cell Liposarcoma – A Rare Tumour Occurring at a Rare Site?
Lipomatous tumours are the most common type of soft tissue neoplasms with liposarcomas being the most common soft tissue sarcomas. Spindle cell liposarcoma is the most recent addition to this group and is characterized b...