FATTY ACID PROFILING AND ANTIOXIDANT POTENTIAL OF TOTAL POLAR LIPID CONTENT OF CYANOBACTERIUM NOSTOC MUSCURUM
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 2
Abstract
Objective: In recent years cyanobacteria has gained much importance due to the presence of secondary metabolites possessing several biological activities like antibacterial, antifungal, anti algal, antiprotozoal, and antiviral activities. Nostoc muscurum, a member of family Nostocaceae, known to have components with potent bioactive properties. The present investigation deals with the analysis of total polar lipids of Nostoc muscurum and its antioxidant potential.Methods: Culture of Nostoc muscurum was grown under lab conditions. Cells were harvested in earlier stationary phase and total polar lipid extracted by modified Bligh and Dyer method. Antioxidant analysis of total polar lipid was done by DPPH free radical method. Finally, total polar lipid was transesterified, and components were identified by GC-MS analysis.Results: Highest percentage inhibition of free radical (65%) was detected at concentration 500 µg/ml which might be due to the presence of bioactive principles hexadecanoic acid. Total twenty-nine compounds were identified through GC-MS analysis. GC-MS analysis revealed that Phthalic acid and 9-Octadecenoic acid, ethyl ester was found in higher concentration in the total polar lipid of Nostoc muscurum as compared to other bioactive compounds. Former is known to possess antimicrobial property while later was found to have bioactive properties like anti-inflammatory, anticancer, hypocholesterolemic, 5-alpha reductase inhibitor and anti androgenic activity.Conclusion: Identified compounds with bioactive properties were mostly organic acids. Also, higher percentage of hydrocarbon was found in the fraction which might be used in the fuel industry. The biological activities of some of the components ranged from antimicrobial, antioxidant and antitumoral activities and can be used in pharmaceutical formulations.Â
Authors and Affiliations
Ananya . , Aisha Kamal
Keywords
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