Fatty liver disease in chronic hepatitis C

Apply

Fatty liver disease in chronic hepatitis C

Journal Title: Postępy Nauk Medycznych - Year 2010, Vol 23, Issue 1

Abstract

In the histological examination of chronic hepatitis C (CHC), necroinflammatory changes, and fibrosis are often accompanied by pathomorphological characteristics of non-alcoholic fatty liver disease (NAFLD). Pathogenesis of metabolic disorders leading to steatosis, with the accompanying progression of inflammation and fibrosis, is multifactorial and not fully characterized. Steatosis in CHC is the consequence of the infection of hepatitis C virus (HCV), which is especially noticeable in the case of infection with HCV genotype 3; it can also be intensified by factors determining the development of NAFLD, as well as by drugs or alcohol. Metabolic changes in CHC in the form of visceral obesity, glucose metabolism disorders and fatty liver are defined as the “virology-metabolic syndrome”. The occurrence of steatosis decreases the effectiveness of antiviral treatment with interferon alpha, and induce the progression to cirrhosis and hepatocellular carcinoma. Further studies are needed to determine the relations between CHC and NAFLD and their effects on the progression of liver disease.

Authors and Affiliations

Andrzej Cieśla, Tomasz Mach

Keywords

Clinically silent pheochromocytoma in a female patient with androgenisation

A 29-year-old female patient was admitted to the Endocrinology Department of CMKP due to androgenisation and hyperanrogeanemia; non-classic congenital adrenal hyperplasia (CAH) was suspected. The patient was diagnosed wi...

Biopsy proven glomarulopathies at the Department of Nephrology, Medical Center for Postgraduate Medicine - analysis of 214 cases

We retrospectively evaluated the results of 214 renal biopsies performed in adult patients at the Department of Nephrology, Medical Centre of Postgraduate Education during 2005-2010. Patient age, indication for renal bio...

EP ID EP53754
DOI -
Views 207
Downloads 0