Fear and Anxiety Behaviour In Mice Was Attenuated Following Chronic Consumption of Musa paradisiaca L. (Musaceae)
Journal Title: Tropical Journal of Natural Product Research - Year 2017, Vol 1, Issue 2
Abstract
Emotions are delicate phenomenon that can affect the whole livelihood, yet to control them physiologically is quite difficult perhaps owing to the paucity in connections between limbic system and neocortex. Many people have devised ways such as consumption of alcohol and hard drugs, to help them control their emotions. Research findings have shown the link between diet and some emotions/neurobehaviour. We investigated the effect of consumption of unripe plantain on fear and anxiety behaviour. Three groups of mice were fed with diet containing 100%, 50% and 0% (control) unripe plantain. Fear and anxiety behaviour was studied using the Light/Dark Transition Box and Elevated Plus Maze tests. The transitions in the light/dark chambers was not significantly (p > 0.05) different among the groups. The light chamber duration of the 100% and 50% plantain diet groups was significantly (p < 0.05) higher than control. Stretch attend postures were lower in 100% and 50% plantain diet groups compared to control. In the Elevated Plus Maze test, frequencies of open arm entry for the 100% and 50% plantain groups were significantly (p < 0.05) higher than control. The difference in open arm entries between 100% and 50% plantain diet groups was significant. The results suggest that consumption of plantain diet reduced fear and anxiety behaviour in mice. A preliminary investigation of the concentration of serotonin in the brains of the mice using High Performance Liquid Chromatography shows that serotonin is significantly (p < 0.001) higher in the 100% plantain diet group than control.
Authors and Affiliations
Peter Erigbali
Keywords
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- EP ID EP349925
- DOI 10.26538/tjnpr/v1i5.10
- Views 83
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