Features of left ventricular remodeling in hypothyroidism and ischemic heart disease on the background of chronic systemic inflammation
Journal Title: Міжнародний ендокринологічний журнал - Year 2019, Vol 15, Issue 2
Abstract
Background. Thyroid dysfunction in modern medical science is regarded as one of the risk factors for cardiovascular diseases, unfortunately, unwittingly underestimated. It is known that even insignificant violations of thyroid function can be accompanied by the increased cardiometabolic risk. Hypothyroidism already on the early (subclinical) stage has a significant influence on formation and development of cardiovascular diseases. The results of large researches demonstrate that subclinical hypothyroidism is associated with increased risk for the development of ischemic heart disease, myocardial infarction and death rate from cardiovascular diseases. The purpose of this research is to study the structural and functional status of the left ventricular myocardium in hypothyroidism, ischemic heart disease and in comorbidity. Materials and methods. One hundred and forty clinical records were analyzed and 55 patients with hypothyroidism, ischemic heart disease and combined pathology were examined. They were divided into 3 groups: the first group — 81 patients with hypothyroidism, the second group — 67 individuals with ischemic heart disease, and the third group — 67 people with combination of hypothyroidism and ischemic heart disease. Control group included 20 persons aged 20 to 25 years. Results. It was found that myocardial hypertrophy developed in all groups of patients; the decrease of thyroid function is characterized by myocardial remodeling with the development of eccentric hypertrophy, with the progression of systolic dysfunction in case of comorbidity. A direct correlation was found between reduced ejection fraction and higher levels of interleukin-8. Conclusions. Activation of chronic systemic inflammation is more significant in comorbidity, with negative prognostic influence on the state of the cardiovascular system. The decline of thyroid function results in the development of left myocardial hypertrophy with subsequent changes in cardiac geometry towards eccentric remodeling. Hypothyroidism is characterized by impaired central hemodynamics; manifestations of systolic dysfunction are increased in combination of thyroid pathology and ischemic heart disease. Activation of chronic systemic inflammation is more significant in comorbidity, with negative prognostic influence on the state of the cardiovascular system.
Authors and Affiliations
O. Yu. Horodynska, L. E. Bobyrova, O. V. Izmailova, A. F. Baranova
Keywords
Related Articles
- EP ID EP605131
- DOI 10.22141/2224-0721.15.2.2019.166104
- Views 76
- Downloads 0
Results of Epidemiological Surveys of Iodine Deficiency Disorders Prevalence in Fergana Region of Republic of Uzbekistan
In spite of extant programs aimed to liquidation of iodine deficiency, Republic of Uzbekistan still remains the zone of high prevalence of iodine deficiency disorders (IDD). Due to epidemiological surveys it has been def...
Influence of ursodeoxycholic acid on insulin resistance in patients with metabolic syndrome
The lecture describes the mechanisms of non-alcoholic fatty liver disease in patients with metabolic syndrome. A comprehensive treatment with the use of ursodeoxycholic acid has reduced the severity of hepatic steatosis,...
Diagnosis and Treatment of Polycystic Ovary Syndrome in Pediatric Gynaecology
Diagnosis of polycystic ovary syndrome (PCOS) in adolescence still raises many questions. The problem is that the characteristics of normal puberty often coincide with PCOS symptoms, so a number of researchers suggest to...
Diagnosis and treatment of thyrotoxicosis during pregnancy and in the postpartum period. A fragment of 2017 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum
In 2017, the American Thyroid Association (ATA) published the guidelines for the diagnosis and treatment of thyroid diseases during pregnancy and the postpartum period [1]. This is the first review of similar ATA recomme...
Features of Type 2 Diabetes Mellitus in Combination with Hypothyroidism
Background. The last decades are characterized by the considerable increase in the prevalence of endocrine disorders with the change of the structure, and first of all cases of polyendocrinopathy, the special place among...