Features of the influence of subclinical hypothyroidism on the cardiovascular system
Journal Title: Медичні перспективи - Year 2017, Vol 22, Issue 4
Abstract
Dysfunction of the thyroid gland has serious consequences for the state of the cardiovascular system. In conditions of deficiency of thyroid hormones, the production of a number of cellular enzymes decreases, that leads to the development of dyslipidemia, insulin resistance, endothelial dysfunction, arterial hypertension, abnormalities in the blood coagulation system, oxidative stress. is a risk factor for cardiovascular disease because associated with dyslipidemia, insulin resistance, arterial hypertension, oxidative stress, endothelial dysfunction, disorders in the blood coagulation system and, thus, atherosclerosis. Subclinical hypothyroidism, as a risk factor for cardiovascular disease, does not have a specific symptomatology, it remains unrecognized for a long time, and by the time the development of manifest hypothyroidism leads to irreversible changes in the cardiovascular system. Detection of abnormalities at the phase of subclinical hypothyroidism and the timely assignment of replacement therapy will avoid an additional risk of cardiovascular pathology. The absence of a unified position in regard to subclinical hypothyroidism does not allow to adopt clear clinical recommendations. Data on the efficacy and need for levothyroxine replacement therapy are contradictory due to the absence of randomized clinical trials. This review article examines mechanisms of the influence of subclinical hypothyroidism on various types of metabolism, methods of diagnosing disorders caused by subclinical hypothyroidism and their modification under the influence of replacement therapy.
Authors and Affiliations
N. O. Pertseva, K. М. Еiner
Keywords
Related Articles
- EP ID EP246082
- DOI 10.26641/2307-0404.2017.4.117667
- Views 100
- Downloads 0
Investigation of the effect of coagulation with high-energy methods of hemostasis implementation on the resected liver surface (experimental research)
The peculiarity of using high-energy methods to implement hemostasis is in difficulty of comparing the degree of exposure to high temperature with the achievement of the desired effect, at the same time, excessive temper...
Оценка микробной обсемененности полости рта пациентов при непереносимости материалов несъемных зубных протезов
Стаття присвячена актуальній проблемі сучасної стоматології - вдосконаленню методів діагностики та профілактики непереносимості незнімних зубних протезів. Автор поставив за мету - підвищити якість профілактики та лікуван...
Порушення внутрішньосерцевої гемодинаміки у дітей з хронічною ревматичною хворобою серця
С помощью допплерэхокардиографии изучены нарушения внутрисердечной гемодинамики у 44 детей в возрасте от 8 до 17 лет с хронической ревматической болезнью сердца и сформированными митральным, аортальным и комбинированными...
Molecular mechanisms of recurrent acute obstructive bronchitis in infants
The article discusses the clinical and immunological features and mechanisms of recurrent acute obstructive bronchitis in infants. We have examined 102 children aged from 6 months to 3 years with acute obstructive...
Ways to improve the results of laparoscopic antireflux operations in patients with big hiatal hernias
The purpose of our study is to evaluate expediency of Platelet-Rich Plasma with self-fixated ProgripTM mesh use in hiatal hernia repair. The study was performed on 144 patients with gastroesophageal reflux with large hia...