Features of the influence of subclinical hypothyroidism on the cardiovascular system
Journal Title: Медичні перспективи - Year 2017, Vol 22, Issue 4
Abstract
Dysfunction of the thyroid gland has serious consequences for the state of the cardiovascular system. In conditions of deficiency of thyroid hormones, the production of a number of cellular enzymes decreases, that leads to the development of dyslipidemia, insulin resistance, endothelial dysfunction, arterial hypertension, abnormalities in the blood coagulation system, oxidative stress. is a risk factor for cardiovascular disease because associated with dyslipidemia, insulin resistance, arterial hypertension, oxidative stress, endothelial dysfunction, disorders in the blood coagulation system and, thus, atherosclerosis. Subclinical hypothyroidism, as a risk factor for cardiovascular disease, does not have a specific symptomatology, it remains unrecognized for a long time, and by the time the development of manifest hypothyroidism leads to irreversible changes in the cardiovascular system. Detection of abnormalities at the phase of subclinical hypothyroidism and the timely assignment of replacement therapy will avoid an additional risk of cardiovascular pathology. The absence of a unified position in regard to subclinical hypothyroidism does not allow to adopt clear clinical recommendations. Data on the efficacy and need for levothyroxine replacement therapy are contradictory due to the absence of randomized clinical trials. This review article examines mechanisms of the influence of subclinical hypothyroidism on various types of metabolism, methods of diagnosing disorders caused by subclinical hypothyroidism and their modification under the influence of replacement therapy.
Authors and Affiliations
N. O. Pertseva, K. М. Еiner
Keywords
Related Articles
- EP ID EP246082
- DOI 10.26641/2307-0404.2017.4.117667
- Views 105
- Downloads 0
Microbial landscape features in patients with generalized periodontitis at pre-clinical and radiological stage of its development
The paper presents the results of a comparative study of microbial landscape features in patients with generalized periodontitis at pre-clinical and radiological stage of its development in 42 patients. The purpose of th...
Comparative assessment of stability of fungicides triazolopyrimidine, triazole, pyrimidine and morpholine in the soil and prediction of groundwater pollution with them
The purpose of our study was prediction of ground water contamination with fungicides of different chemical classes in soil-climatic conditions of Ukraine and other European countries and hygienic assessment of their har...
Peculiarities of coagulation hemostasis disorders in patients with chronic obstructive pulmonary disease
The violation of blood coagulation properties is observed in many diseases of the respiratory system, including chronic obstructive pulmonary disease (COPD). It is known that in a stable COPD phase release of proinflamma...
Significance of free radical oxidation in purulent process development in patients with chronic generalized periodontitis I-II severity degree
The results of the comparative study and the importance of free radical oxidation in causing purulent process in 46 patients with chronic generalized periodontitis I-II severity degree are presented. The aim - to study t...
Соматоформные расстройства в практике семейного врача
Соматоформні розлади - психогенні захворювання, що характеризуються фізичними патологічними симптомами, які нагадують соматичне захворювання. При цьому не виявляється ніяких органічних проявів, які можна зарахувати до ві...