Features of the nervous system lesion in primary hypothyroidism (literature review)
Journal Title: Міжнародний ендокринологічний журнал - Year 2018, Vol 14, Issue 2
Abstract
The review presents the pathogenetic mechanisms of central and peripheral nervous system pathology in primary hypothyroidism. Lack of thyroid hormones leads to changes in the organization of the central nervous system, decrease in the energy supply of neurons, changes in the synthesis of some specific proteins of the nervous system that cause the development of cretinism in children. The role of hypothyroidism in the development of cognitive impairment in adults, such as decreased cognitive function, memory and attention, has been proved. The impairment of logical thinking is found already in patients with subclinical hypothyroidism. Disorders in mediation exchange lead to the development of depression. Neuromuscular disorders (hypothyroid myopathy and myotonic phenomenon) and affection to the peripheral nerves are best studied in hypothyroidism. Primary hypothyroidism may be masked by tunnel neuropathy, polyneuropathy and atactic syndrome. Despite the existing papers on the problem of hypothyroidism and its neurological complications, some issues of pathogenesis, diagnosis, course and treatment of neurological pathology in primary hypothyroidism require further research.
Authors and Affiliations
I. I. Bilous, L. B. Pavlovych
Keywords
Related Articles
- EP ID EP299534
- DOI 10.22141/2224-0721.14.2.2018.130563
- Views 49
- Downloads 0
Anemia in Vascular Complications Development Associated with Diabetes Mellitus: Is It a Reason or Consequence?
The patients with cardiorenal anemic syndrome are considered to be the most serious ones with a high cardiorenal risk related to mutual negative impact of severe pathological conditions. The presence of cardiorenal anemi...
Relation between Hormonal Disorders and Components of Metabolic Syndrome in Patients with Primary Hypothyroidism
During the last decade plenty of the researches dedicated to the problem of hypothyroidism were published, that radically changed views to the value of thyroid pathology on the whole. Neurohumoral changes are considered...
Features of nephropathy in obese patients with type 2 diabetes mellitus
Background. The article describes the results of the studies of diabetic nephropathy in obese patients with type 2 diabetes mellitus (DM). The aim of the study is to investigate the combination of obesity and renal patho...
Thyroid nodules in the population of Ukraine, protocol of diagnosis and treatment after the Chernobyl accident (literature review and own data)
The article describes the current understanding of the pathogenesis of different types of thyroid nodules. An algorithm for the diagnosis of thyroid diseases, which is aimed at verifying the morphological structure of go...
Snps Gln27Glu Polymorphism of β2-Adrenoceptor Gene and Carbohydrate and Lipid Metabolism Impairment in Obese Patients with Ischemic Heart Disease
This article estimates the role of Gln27Glu polymorphism of β2-adrenergic receptors gene in forming violations of carbohydrate and lipid metabolism in obese patients with ischemic heart disease. A comprehensive survey of...