Fentanyl-clonidine and fentanyl-lidocaine on attenuation of haemodynamic stress response to laryngoscopy and tracheal intubation laparoscopic surgery- A comparative study
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 9
Abstract
Introduction: Endotracheal intubation creates a period of hemodynamic instability in normotensive patients. Endotracheal intubation produces stimulation of laryngeal and tracheal sensory receptors, resulting in a marked increase in the elaboration of sympathetic amines leading to hypertensive crisis. Objectives: The objective of study is to evaluate and compare the efficacy of fentanyl- clonidine and fentanyl – lidocaine combine in attenuating the stress responses to laryngoscopy and endotracheal intubation in nermotensive patients. Material and Methods: We conducted a prospective, randomized, double-blind study in 40 patients posted for laparoscopic surgery. All patients were randomly divided into two groups, fentanyl-clonidine (FC) group and fentanyl – lidocaine (FL) group. The FC group received Fentanyl 2 mcg/kg and clonidine 2mcg/kg and the FL group received lidocaine1.5mg/kg and fentanyl 2mcg/kg , 3 min prior to intubation. Hemodynamic parameters were recorded at baseline, after giving induction agents, and 1, 3 and 5 minutes after endotracheal intubation. Results: There were no significant differences between the two groups regarding hemodynamic parameters like heart rate, systolic blood pressure, diastolic and mean arterial blood pressure at before induction, 1, 3 and 5 minutes after intubation. Conclusions: Both fentanyl – clonidine and fentanyl – lidocaine combine effectively decreased the stress response to endotracheal intubation.
Authors and Affiliations
Basant Kumar Pradhan, Khagaswar Raut, Sidharth Sraban Routray, Debasis Mishra
Keywords
Related Articles
- EP ID EP193550
- DOI -
- Views 86
- Downloads 0
Comparative study of modified Blumenthal and Ruit technique for manual small- incision cataract surgery (MSICS)
Aim: To compare the efficacy and visual results of the modified Blumenthal and Ruit techniques for manual small-incision cataract surgery (MSICS). Methodology: This was a prospective, non-randomized comparison of 129 pat...
A study of the factors associated with recurrence of pilonidal sinus at tertiary health care centers
Introduction: Pilonidal sinus disease (PSD), diagnosed by the penetration of hair follicles into one or more sinus walls, attacks younger subjects more frequently and chronically develops with acute and sub acute instanc...
Study of cytomorphological features of hashimoto’s thyroiditis and their correlation with serological findings
Introduction: Hashimoto’s thyroiditis is an autoimmune disease that most often affects middle aged females. This study highlights the cytomorphological featuserological findings. Res of HT and helps to define a grading c...
Clinical profile of pulmonary tuberculosis in HIV patients
Background: Mycobacterium tuberculosis infection is very common in HIV patients. 120 cases of HIV-positive cases were screened for TB who were clinically diagnosed as Pulmonary Tuberculosis during the study period from J...
A comparative study of hernia with respect to visual analogue scale for post-operative pain
Introduction: Inguinal hernia repair surgeries are among the commonest general surgical procedures performed worldwide and hence due effort has been taken over the years to reduce the morbidity associated with them. Post...