Fertility preservation in male patients subjected to chemotherapy; innovative approaches for further progress
Journal Title: Turkish Journal of Obstetrics and Gynecology - Year 2017, Vol 14, Issue 4
Abstract
About 4% of male patients with cancer are under the age of 35 years. With the current increase in efficacy and safety of therapies, a growing number of young adults can achieve long-term survival. In male patients receiving systemic chemotherapy and or bone marrow transplantation, a permanent loss of fertility is a common adverse effect. The only possibility to preserve the patient’s fertility is to spare the gametes or gamete-forming cells from the chemotherapeutic effect. In adults, this can be achieved by the cryopreservation of spermatozoa with the subsequent application of assisted reproductive technology. Sperm cryopreservation is currently performed using slow-rate cryopreservation as a standard method, in which sperm cells are incubated with a cryoprotective medium and slowly subjected to hypothermia in liquid nitrogen (LN) vapor before they are placed in LN. Another technique called vitrification relies on the direct placement of the cells into LN, after being suspended in a vitrification medium. Many studies compared the clinical outcomes of both techniques and revealed equivalent results. This paper sheds light on some innovative approaches for further progress.
Authors and Affiliations
Mohamed Shehata
Keywords
Related Articles
- EP ID EP365067
- DOI 10.4274/tjod.84565
- Views 119
- Downloads 0
Clinical analyses of successful and previously failed intracytoplasmic sperm injection cycle parameters in patients with poor ovarian reserve
Objective: To determine some major characteristic differences between two consecutive successful and unsuccessful intracytoplasmic sperm injection (ICSI) cycles in poor responders. Materials and Methods: Sixty women with...
Subclinical hypothyroidism: Is it important in intracytoplasmic sperm injection cycles?
Objective: To compare intracytoplasmic sperm injection (ICSI) outcomes of women with subclinical hypothyroidism with those of euthyroid women. Materials and Methods: A retrospective case-control study was conducted. Out...
Comparison of bupivacaine and ropivacaine in combination with fentanyl used for walking epidural anesthesia in labor
Objective: Effective pain relief during labor is essential to reduce maternal and perinatal morbidity arising due to pain-induced maternal sympathetic activation, and to avoid unnecessary cesarean sections performed due...
A comparison of normal and high post-void residual urine and urodynamic parameters in women with overactive bladder
Objective To investigate voiding functions and assess the relationships of voiding parameters to overactive bladder symptoms and postvoiding residue volumes. Materials and Methods This is a retrospective study analyzing...
Chondrosarcoma mimicking an adnexal mass: A very rare case report
Chondrosarcoma is considered as a common primary bone sarcoma. These sarcomas can form large masses without any specific symptoms because there are no barriers in pelvic anatomy to prevent the enlargement of tumors, and...