Fibre Diet for Antipsychotic induced Hyperlipidemia: A review
Journal Title: Scholars Academic Journal of Pharmacy - Year 2014, Vol 3, Issue 6
Abstract
The Dietary fibers are known for their cholesterol lowering effect. Dietary fibers are found in all plant based foods.. Soluble fibers pulls in water to form a gel in the digestive tract. This slows digestion, so that stomach and intestine don’t absorb as much of some nutrients, like starch and sugar. Insoluble fiber can be found in the peels of fruits such as apples, blueberries and grapes. It acts as a natural laxative that speeds the passage of foods through the stomach and gives stool its bulk and helps it move quickly through the gastrointestinal tract. Dietary and pharmacological reduction in total and LDL cholesterol decreases the risk of coronary diseases and dietary intervention is the desirable approach. Antipsychotic medication shows some side effects generally weight gain, high cholesterol level and may increase in risk of diabetes, risk of heart disease, stroke and diabetes and common side effects are blurred vision, dry mouth, drowsiness muscle spasm or tremors. To control over these side effect of increased level of cholesterol lipid profile in the blood, soluble and insoluble fiber diets are administered which decreased the lipid level in the body. Fibers like guar gum has been found to be associated with a 10% reduction in apetite and increase in the feeling of satiety. Fiber reduces cholesterol by multiple mechanisms, namely, interruption of enterohepatic circulation of the bile acids with enhanced bile seceretion, and inhibition of cholesterol absorbtion leading to increased excretion of neutral sterols; additionally guar may entrap fat micelles thereby impending fat absorbtion. The present study highlights about the effect of soluble and insoluble fiber diet on atypical antipsychotic agents induced hyperlipidemia. Keywords: Laxative, Total cholesterol, LDL cholesterol, Coronary disease, Drowsiness, Tremors, Postprandial glycemia, Insulinaemia, Enterrohepatic circulation, Cholestrol absorbtion, Neutral sterol
Authors and Affiliations
Goswami Nupur, Das Sanjita ,, Diksha ,
Keywords
Related Articles
- EP ID EP378104
- DOI -
- Views 122
- Downloads 0
Validation: A Significant Tool for Enhancing Qualities of Pharmaceutical Products
Validation means confirmation of quality by with the documentation system. Quality is the main aspect of every pharmaceutical company and it is achieved with the help of validation process. Validation is the documented e...
Changes in the Amounts of Amoxicillin and Metronidazole Used for Helicobacter pylori Eradication Therapy in the Stomach after Their Oral Administration to Rats
In the eradication therapy of Helicobacter pylori, the changes of the amounts and concentrations of antibiotics in the stomach after oral administration were unclear. Amoxicillin (AMX) and metronidazole (MTZ), which are...
Effect of Preservative in the Physicochemical Stability of Cosmetic Products Based on Natural Resources from Costa Rican Flora
A problem of rural women in Latin America is the poor access to economic resources; a solution we propose is to implement a collaborative model, where are used natural resources in the area for production of value added...
Development and Validation of Analytical Method for Simultaneous Estimation of Amoxicillin and Probenecid in Bulk and Tablet Dosage form using HPLC
A simple Reverse Phase High Performance Liquid Chromatographic (RP-HPLC) method is reported for the simultaneous determination of Amoxicillin and Probenecid in oral dosage forms. Investigated drugs were resolved on BDS h...