Fibroid explants reveal a higher sensitivity against MDM2-inhibitor nutlin-3 than matching myometrium
Journal Title: BMC Women's Health - Year 2012, Vol 12, Issue
Abstract
Spontaneous cessation of growth is a frequent finding in uterine fibroids. Increasing evidence suggests an important role of cellular senescence in this growth control. Deciphering the underlying mechanisms of growth control that can be expected not only to shed light on the biology of the tumors but also to identify novel therapeutic targets.
Authors and Affiliations
Dominique N Markowski, Burkhard M Helmke, Arlo Radtke, Jennifer Froeb, Gazanfer Belge, Sabine Bartnitzke, Werner Wosniok, Iris Czybulka-Jachertz, Ulrich Deichert, Jörn Bullerdiek
Keywords
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- EP ID EP679509
- DOI 10.1186/1472-6874-12-2
- Views 29
- Downloads 0
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